BACKGROUND: Preoperative transcatheter arterial chemoembolization (TACE) is administered to improve long-term outcome after surgical resection of hepatocellular carcinoma (HCC). However, the survival benefit of preoperative TACE is controversial. We conducted a retrospective case-control study to evaluate the effect of preoperative TACE on prognosis. METHODS: A total of 121 patients who underwent curative resection of HCC were divided into two groups according to whether they received preoperative TACE. We determined the control group (n = 34) and TACE group (n = 34) through propensity score matching. The primary endpoint of this study was overall survival, and the secondary endpoints were recurrence-free survival. RESULTS: The overall survival rate and the recurrence free survival rate were significantly lower in the TACE group than in the control group (P = 0.014 and P = 0.043, respectively). Furthermore, recurrence free survival within less than 2 years after resection was significantly worse in the TACE group than in the control group (P = 0.035). CONCLUSION: Preoperative TACE seemed to worsen the long-term outcomes of the patients who underwent surgical resection for the treatment of resectable HCC. Therefore, preoperative TACE should not be considered as a standard therapy in patients with resectable HCC.
BACKGROUND: Preoperative transcatheter arterial chemoembolization (TACE) is administered to improve long-term outcome after surgical resection of hepatocellular carcinoma (HCC). However, the survival benefit of preoperative TACE is controversial. We conducted a retrospective case-control study to evaluate the effect of preoperative TACE on prognosis. METHODS: A total of 121 patients who underwent curative resection of HCC were divided into two groups according to whether they received preoperative TACE. We determined the control group (n = 34) and TACE group (n = 34) through propensity score matching. The primary endpoint of this study was overall survival, and the secondary endpoints were recurrence-free survival. RESULTS: The overall survival rate and the recurrence free survival rate were significantly lower in the TACE group than in the control group (P = 0.014 and P = 0.043, respectively). Furthermore, recurrence free survival within less than 2 years after resection was significantly worse in the TACE group than in the control group (P = 0.035). CONCLUSION: Preoperative TACE seemed to worsen the long-term outcomes of the patients who underwent surgical resection for the treatment of resectable HCC. Therefore, preoperative TACE should not be considered as a standard therapy in patients with resectable HCC.
Authors: Won Jin Ho; Gaurav Sharma; Qingfeng Zhu; Genevieve Stein-O'Brien; Jennifer Durham; Robert Anders; Aleksandra Popovic; Guanglan Mo; Ihab Kamel; Matthew Weiss; Elizabeth Jaffee; Elana J Fertig; Mark Yarchoan Journal: J Immunother Cancer Date: 2020-11 Impact factor: 13.751