Koki Nakanishi1, Shota Fukuda2, Hajime Yamashita1, Toshifumi Hasegawa1, Michihiko Kosaka1, Naoya Shirai1, Kenei Shimada3, Junichi Yoshikawa4, Atsushi Tanaka5. 1. Department of Cardiovascular Medicine, Baba Memorial Hospital, 4-244 Hamaderafunaocho-higashi, Nishi-ku, Sakai, Japan. 2. Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. 3. Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan. 4. Nishinomiya Watanabe Cardiovascular Center, Nishinomiya, Japan. 5. Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
Abstract
AIMS: We aimed to determine whether elevated serum high-sensitive cardiac troponin T (hs-TnT) levels predict atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). METHODS AND RESULTS: We included 125 consecutive patients with AF (paroxysmal, n = 79; persistent, n = 46) who underwent first-time PVI. Serum hs-TnT, high-sensitive C-reactive protein (hs-CRP), atrial natriuretic peptide, and plasma B-type natriuretic peptide levels were measured in venous samples collected before PVI. Elevated hs-TnT was diagnosed in patients with levels ≥0.014 μg/L. All patients underwent multidetector computed tomographic examinations before PVI to measure left atrial volume (LAV) and left ventricular (LV) mass, which were indexed to body surface area. Arrhythmia recurrence was defined as AF/atrial tachycardia episodes lasting for ≥30 s after a 2-month blanking period from the PVI procedure. Elevated hs-TnT levels were observed in 22 (17.6%) patients. Age, diabetes mellitus, LV mass index, estimated glomerular filtration rate, and hs-CRP were independently associated with serum hs-TnT levels (all P < 0.05). During a mean follow-up of 12.9 ± 8.5 months after a single PVI procedure, the clinical recurrence rate was 33% (n = 41). Multivariate Cox proportional hazard analysis revealed that a greater LAV index (P = 0.01) and elevated serum hs-TnT level (P = 0.01) were significant predictors of AF recurrence after PVI. CONCLUSION: This study demonstrated that elevated serum hs-TnT levels are associated with AF recurrence independent of traditional risk factors and left atrial enlargement. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: We aimed to determine whether elevated serum high-sensitive cardiac troponin T (hs-TnT) levels predict atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). METHODS AND RESULTS: We included 125 consecutive patients with AF (paroxysmal, n = 79; persistent, n = 46) who underwent first-time PVI. Serum hs-TnT, high-sensitive C-reactive protein (hs-CRP), atrial natriuretic peptide, and plasma B-type natriuretic peptide levels were measured in venous samples collected before PVI. Elevated hs-TnT was diagnosed in patients with levels ≥0.014 μg/L. All patients underwent multidetector computed tomographic examinations before PVI to measure left atrial volume (LAV) and left ventricular (LV) mass, which were indexed to body surface area. Arrhythmia recurrence was defined as AF/atrial tachycardia episodes lasting for ≥30 s after a 2-month blanking period from the PVI procedure. Elevated hs-TnT levels were observed in 22 (17.6%) patients. Age, diabetes mellitus, LV mass index, estimated glomerular filtration rate, and hs-CRP were independently associated with serum hs-TnT levels (all P < 0.05). During a mean follow-up of 12.9 ± 8.5 months after a single PVI procedure, the clinical recurrence rate was 33% (n = 41). Multivariate Cox proportional hazard analysis revealed that a greater LAV index (P = 0.01) and elevated serum hs-TnT level (P = 0.01) were significant predictors of AF recurrence after PVI. CONCLUSION: This study demonstrated that elevated serum hs-TnT levels are associated with AF recurrence independent of traditional risk factors and left atrial enlargement. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Ivan Zeljkovic; Sven Knecht; Florian Spies; Tobias Reichlin; Beat Schaer; Stefan Osswald; Michael Kühne; Christian Sticherling Journal: Biochem Med (Zagreb) Date: 2019-06-15 Impact factor: 2.313
Authors: Ivan Zeljkovic; Sven Knecht; Nikola Pavlovic; Umut Celikyrut; Florian Spies; Sarah Burri; Dominik Mannhart; Loris Peterhans; Tobias Reichlin; Beat Schaer; Stefan Osswald; Christian Sticherling; Michael Kuhne Journal: Open Heart Date: 2019-04-20