| Literature DB >> 28068839 |
Xiaowei Luo1,2, Xuefeng Zhou1, Xiuping Lin1, Xiaochu Qin3, Tianyu Zhang3, Junfeng Wang1, Zhengchao Tu3, Bin Yang1, Shengrong Liao1, Yongqi Tian1, Xiaoyan Pang1,2, Kumaravel Kaliyaperumal1, Jian Lin Li4, Huaming Tao5, Yonghong Liu1,6.
Abstract
Eleven diketopiperazine and fumiquinazoline alkaloids (1-11) together with a tetracyclic triterpenoid helvolic acid (12) were obtained from the cultures of a deep-sea derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of these compounds (1-12) were determined mainly by the extensive NMR, ESIMS spectra data and by comparison with previously described compounds. Besides, anti-tuberculosis, cytotoxic, antibacterial, COX-2 inhibitory and antiviral activities of these compounds were evaluated. Gliotoxin (3), 12,13-dihydroxy-fumitremorgin C (11) and helvolic acid (12) exhibited very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the prominent MIC50 values of <0.03, 2.41 and 0.894 μM, respectively, which was here reported for the first time. Meanwhile gliotoxin also displayed significant selective cytotoxicities against K562, A549 and Huh-7 cell lines with the IC50 values of 0.191, 0.015 and 95.4 μM, respectively.Entities:
Keywords: Aspergillus sp; Deep sea fungi; alkaloids; anti-tuberculosis
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Year: 2017 PMID： 28068839 DOI： 10.1080/14786419.2016.1266353
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861