Literature DB >> 2806803

Familial Crohn's disease in multiple siblings: no linkage to the HLA system.

J F Colombel1, F Guillemot, A Van Gossum, F Dufossé, A Cortot, E Dupont, J C Paris.   

Abstract

We report five families with 3 or more children having Crohn's disease. In one family, 6 out of 11 siblings were affected. HLA haplotype study in affected children showed that the probability of random segregation was only 38 percent, making improbable a linkage between the histocompatibility locus and the development of Crohn's disease. However similar clinical patterns in siblings could suggest a genetic factor not linked to the HLA system.

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Year:  1989        PMID： 2806803

Source DB:  PubMed          Journal:  Gastroenterol Clin Biol        ISSN： 0399-8320


  6 in total

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Authors:  Bing Xia; JBA Crusius; SGM Meuwissen; AS Pe?a
Journal:  World J Gastroenterol       Date:  1998-10       Impact factor: 5.742

2.  HLA class II genes in primary sclerosing cholangitis and chronic inflammatory bowel disease: no HLA-DRw52a association in Swedish patients with sclerosing cholangitis.

Authors:  H Zetterquist; U Broomé; K Einarsson; O Olerup
Journal:  Gut       Date:  1992-07       Impact factor: 23.059

3.  Analysis of the contribution of HLA genes to genetic predisposition in inflammatory bowel disease.

Authors:  I Naom; J Lee; D Ford; S J Bowman; J S Lanchbury; I Haris; S V Hodgson; D Easton; J Lennard-Jones; C G Mathew
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

4.  Crohn's disease: the genetic contribution.

Authors:  J Sofaer
Journal:  Gut       Date:  1993-07       Impact factor: 23.059

5.  Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses.

Authors:  H Yang; S E Plevy; K Taylor; D Tyan; N Fischel-Ghodsian; C McElree; S R Targan; J I Rotter
Journal:  Gut       Date:  1999-04       Impact factor: 23.059

6.  An in-depth study of Crohn's disease in two French families.

Authors:  H J Van Kruiningen; J F Colombel; R W Cartun; R H Whitlock; M Koopmans; H O Kangro; J A Hoogkamp-Korstanje; M Lecomte-Houcke; M Devred; J C Paris
Journal:  Gastroenterology       Date:  1993-02       Impact factor: 22.682
  6 in total

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