Domitille Fiaux-Camous1, Sylvie Chevret2, Natalie Oker1, Mario Turri-Zanoni3, Davide Lombardi4, Olivier Choussy5, Frederic Duprez6, Marc Jorissen7, Ludovic de Gabory8, Olivier Malard9, Philippe Herman1, Piero Nicolai4, Paolo Castelnuovo3, Benjamin Verillaud1. 1. Ear, Nose, and Throat Department, Lariboisière University Hospital, Paris, France. 2. Biostatistics and Clinical Epidemiology (ECSTRA) Team, UMR 1153 Inserm, Paris Diderot University, Saint-Louis Hospital, AP-HP, Paris, France. 3. Department of Otorhinolaryngology, Insubria University, Varese, Italy. 4. Department of Otorhinolaryngology, University of Brescia, Brescia, Italy. 5. Ear, Nose, and Throat Department, Rouen University Hospital, Rouen, France. 6. Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium. 7. Department of Otorhinolaryngology - Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium. 8. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bordeaux, F-X Michelet Center, Bordeaux Cedex, France. 9. Ear, Nose, and Throat Department, CHU Hôtel-Dieu, Nantes, France.
Abstract
BACKGROUND: The purpose of this study was to propose a prognostic classification of intestinal-type adenocarcinoma (ITAC) based on literature search and prognostic modeling of cohort data. METHODS: We first conducted a literature search to assess the homogeneity of the reported estimates of 5-year survival and to identify the influence of T classification. We then pooled prospective data from 3 large French and Italian series to predict time to all-cause mortality. The sample was randomly split to derive and then to validate the proposed prognostic model. RESULTS: Literature analysis confirmed the heterogeneity in 5-year survival rates, partly explained in subsets of homogeneous T-values. The sample included 223 patients, randomly separated into a derivation (n = 141) and a validation set (n = 82). Invasion of the sphenoid lateral and/or posterior walls and dura/cerebral invasion were systematically associated with a poor survival. CONCLUSION: The incorporation of the invasion of the sphenoid lateral or posterior walls should be considered for ITAC management and prognostication.
BACKGROUND: The purpose of this study was to propose a prognostic classification of intestinal-type adenocarcinoma (ITAC) based on literature search and prognostic modeling of cohort data. METHODS: We first conducted a literature search to assess the homogeneity of the reported estimates of 5-year survival and to identify the influence of T classification. We then pooled prospective data from 3 large French and Italian series to predict time to all-cause mortality. The sample was randomly split to derive and then to validate the proposed prognostic model. RESULTS: Literature analysis confirmed the heterogeneity in 5-year survival rates, partly explained in subsets of homogeneous T-values. The sample included 223 patients, randomly separated into a derivation (n = 141) and a validation set (n = 82). Invasion of the sphenoid lateral and/or posterior walls and dura/cerebral invasion were systematically associated with a poor survival. CONCLUSION: The incorporation of the invasion of the sphenoid lateral or posterior walls should be considered for ITAC management and prognostication.