Vladimir Stanislavovich Rogovskii 1 Show Affiliations »
Abstract
BACKGROUND: It is widely accepted that chronic inflammation critically contributes to cancer. Immune tolerance in cancer mediates tumor escape from the immune system. The mechanisms of relations between inflammation and immune tolerance are still not fully elucidated. OBJECTIVE: The main mechanisms that link inflammation and tolerance are considered. Drug targets that are in use to interfere with inflammation in cancer are discussed. CONCLUSION: Inflammation mediates tumor-induced tolerance. The induction and the maintenance of the chronic inflammatory response is a universal mechanism of immune tolerance. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: It is widely accepted that chronic inflammation critically contributes to cancer . Immune tolerance in cancer mediates tumor escape from the immune system. The mechanisms of relations between inflammation and immune tolerance are still not fully elucidated. OBJECTIVE: The main mechanisms that link inflammation and tolerance are considered. Drug targets that are in use to interfere with inflammation in cancer are discussed. CONCLUSION: Inflammation mediates tumor -induced tolerance. The induction and the maintenance of the chronic inflammatory response is a universal mechanism of immune tolerance. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Disease
Keywords:
Inflammation; cancer immunotherapy; immune tolerance; resolution; tumor immunology; tumor-induced tolerance
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Year: 2017
PMID： 28067176 DOI： 10.2174/1568009617666170109110816
Source DB: PubMed Journal: Curr Cancer Drug Targets ISSN： 1568-0096 Impact factor: 3.428