| Literature DB >> 28067066 |
Qing-Long Liu1,2, A-Hong Chen1,2, Jin-Ying Tang1,2, Yan-Lei Ma1,2, Zhi-Hua Jiang1,2, Yan-Ping Liu2, Guang-Ying Chen1,2, Yan-Hui Fu1,2, Wei Xu1.
Abstract
A new indole alkaloid, 17-O-methyl-19-(Z)-naucline (1), together with seven known alkaloids (2-8), were isolated from the stems and leaves of Nauclea officinalis. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literature. 17-O-methyl-19-(Z)-naucline (1) showed significant inhibitory activity on nitric oxide production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with an IC50 value of 3.6 μM.Entities:
Keywords: Nauclea officinalis; anti-inflammatory activity; indole alkaloid; nitric oxide production
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Year: 2017 PMID： 28067066 DOI： 10.1080/14786419.2016.1277351
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861