Nam Hee Kim1, Jung Ho Park1, Dong Il Park1, Chong Il Sohn1, Kyuyong Choi1, Yoon Suk Jung2. 1. Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 2. Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: ys810.jung@samsung.com.
Abstract
BACKGROUND: In contrast to the decreasing incidence of colorectal cancer (CRC) in adults ≥50 years, the CRC incidence in young adults <50 years is increasing. The fecal immunochemical test (FIT) may be useful for advanced colorectal neoplasia (ACRN) screening in a young population. AIMS: To evaluate the diagnostic accuracy of FIT in a young population. METHODS: The diagnostic performance of FIT for detecting ACRN was compared among the following age groups who underwent FIT and colonoscopy as part of a comprehensive health screening program: 30-39, 40-49, and ≥50 years. RESULTS: Of 26,316 participants, 464 (1.8%) had ACRN and 805 (3.1%) showed positive FIT results. No significant differences in the sensitivity (22.1%, 17.2%, and 22.0%; p=0.435) and specificity (97.2%, 97.4%, and 96.9%; p=0.344) of FIT for detecting ACRN were observed among the groups. However, 30-39 age group had a significantly higher accuracy of FIT for ACRN (96.7%) than 40-49 and ≥50 age groups (95.9% and 93.8%; p<0.001). The areas under the receiver operating characteristic curves of FIT for ACRN of three age groups were not significantly different (67.2, 66.2, and 61.7; p=0.952). CONCLUSIONS: The diagnostic performance of FIT for ACRN in a young population (<50 years) was not inferior to that in the current screening-age population (≥50 years). The FIT may be a good choice for detecting ACRN in a young population.
BACKGROUND: In contrast to the decreasing incidence of colorectal cancer (CRC) in adults ≥50 years, the CRC incidence in young adults <50 years is increasing. The fecal immunochemical test (FIT) may be useful for advanced colorectal neoplasia (ACRN) screening in a young population. AIMS: To evaluate the diagnostic accuracy of FIT in a young population. METHODS: The diagnostic performance of FIT for detecting ACRN was compared among the following age groups who underwent FIT and colonoscopy as part of a comprehensive health screening program: 30-39, 40-49, and ≥50 years. RESULTS: Of 26,316 participants, 464 (1.8%) had ACRN and 805 (3.1%) showed positive FIT results. No significant differences in the sensitivity (22.1%, 17.2%, and 22.0%; p=0.435) and specificity (97.2%, 97.4%, and 96.9%; p=0.344) of FIT for detecting ACRN were observed among the groups. However, 30-39 age group had a significantly higher accuracy of FIT for ACRN (96.7%) than 40-49 and ≥50 age groups (95.9% and 93.8%; p<0.001). The areas under the receiver operating characteristic curves of FIT for ACRN of three age groups were not significantly different (67.2, 66.2, and 61.7; p=0.952). CONCLUSIONS: The diagnostic performance of FIT for ACRN in a young population (<50 years) was not inferior to that in the current screening-age population (≥50 years). The FIT may be a good choice for detecting ACRN in a young population.
Authors: Kevin Selby; Christopher D Jensen; Jeffrey K Lee; Chyke A Doubeni; Joanne E Schottinger; Wei K Zhao; Jessica Chubak; Ethan Halm; Nirupa R Ghai; Richard Contreras; Celette Skinner; Aruna Kamineni; Theodore R Levin; Douglas A Corley Journal: Ann Intern Med Date: 2018-09-18 Impact factor: 25.391
Authors: Kevin Selby; Emma H Levine; Cecilia Doan; Anton Gies; Hermann Brenner; Charles Quesenberry; Jeffrey K Lee; Douglas A Corley Journal: Gastroenterology Date: 2019-08-22 Impact factor: 22.682
Authors: Charles R Rogers; Tiana N Rogers; Phung Matthews; Nathan Le Duc; Susan Zickmund; Wizdom Powell; Roland J Thorpe; Alicia McKoy; France A Davis; Kola Okuyemi; Electra D Paskett; Derek M Griffith Journal: Ethn Health Date: 2020-11-29 Impact factor: 2.732