Literature DB >> 2806562

Cloning and sequence analysis of cDNA for precursor of a crustacean hyperglycemic hormone.

W Weidemann1, J Gromoll, R Keller.   

Abstract

Crustacean hyperglycemic hormone (CHH) from Carcinus maenas, a 72 amino acid neuropeptide, originates in neurosecretory perikarya in the eyestalk ganglia. Poly (A)RNA was isolated from these perikarya and a cDNA library was prepared. Screening of 20,000 clones with a 26-mer oligonucleotide, corresponding to a partial sequence of CHH, yielded one positive clone with an insert of approximately 2,000 bp, which contained the complete coding sequence for a pre-pro CHH. This precursor consists of a putative 26 amino acid signal sequence, a 38 amino acid peptide of unknown function (Peptide C), and the CHH sequence at the carboxyl end. The CHH-sequence is flanked N-terminally by a Lys-Arg cleavage site and C-terminally by the tetrapeptide Gly-Arg-Lys-Lys which is followed by the stop codon.

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Year:  1989        PMID： 2806562     DOI： 10.1016/0014-5793(89)81778-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  A remarkable, precisely timed release of hyperglycemic hormone from endocrine cells in the gut is associated with ecdysis in the crab Carcinus maenas.

Authors:  J S Chung; H Dircksen; S G Webster
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

Review 2.  Crustacean neuropeptides: structures, functions and comparative aspects.

Authors:  R Keller
Journal:  Experientia       Date:  1992-05-15

3.  Autoradiographic evidence that transport of newly synthesized neuropeptides is directed to release sites in the X-organ--sinus gland of Cardisoma carnifex.

Authors:  E Stuenkel; E Gillary; I Cooke
Journal:  Cell Tissue Res       Date:  1991-05       Impact factor: 5.249

Review 4.  Regulation of crustacean neurosecretory cell activity.

Authors:  U García; H Aréchiga
Journal:  Cell Mol Neurobiol       Date:  1998-02       Impact factor: 5.046

5.  Crustacean hyperglycaemic hormone (CHH)-like peptides and CHH-precursor-related peptides from pericardial organ neurosecretory cells in the shore crab, Carcinus maenas, are putatively spliced and modified products of multiple genes.

Authors:  H Dircksen; D Böcking; U Heyn; C Mandel; J S Chung; G Baggerman; P Verhaert; S Daufeldt; T Plösch; P P Jaros; E Waelkens; R Keller; S G Webster
Journal:  Biochem J       Date:  2001-05-15       Impact factor: 3.857

6.  Fine structure of the neurohemal sinus gland of the shore crab, Carcinus maenas, and immuno-electron-microscopic identification of neurosecretory endings according to their neuropeptide contents.

Authors:  H Dircksen
Journal:  Cell Tissue Res       Date:  1992-08       Impact factor: 5.249

7.  High-level secretion of hirudin by Hansenula polymorpha--authentic processing of three different preprohirudins.

Authors:  U Weydemann; P Keup; M Piontek; A W Strasser; J Schweden; G Gellissen; Z A Janowicz
Journal:  Appl Microbiol Biotechnol       Date:  1995-12       Impact factor: 4.813

8.  Novel protocol for the chemical synthesis of crustacean hyperglycemic hormone analogues--an efficient experimental tool for studying their functions.

Authors:  Alessandro Mosco; Vientsislav Zlatev; Corrado Guarnaccia; Sándor Pongor; Antonella Campanella; Sotir Zahariev; Piero G Giulianini
Journal:  PLoS One       Date:  2012-01-11       Impact factor: 3.240

9.  cDNA cloning of a mandibular organ inhibiting hormone from the spider crab Libinia emarginata.

Authors:  L Liu; H Laufer; P J Gogarten; M Wang
Journal:  Invert Neurosci       Date:  1997 Sep-Dec
  9 in total

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