Todd P Whitehead1, Praphopphat Adhatamsoontra2, Yang Wang2, Elisa Arcolin3, Leonard Sender4, Steve Selvin2, Catherine Metayer2. 1. School of Public Health, University of California, Berkeley. Electronic address: ToddPWhitehead@Berkeley.edu. 2. School of Public Health, University of California, Berkeley. 3. Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy. 4. School of Medicine, University of California, Irvine.
Abstract
PURPOSE: We investigated the relationship between the risk of childhood leukemia and home remodeling, a surrogate for indoor chemical exposures. METHODS: We collected information on remodeling activities carried out between birth and diagnosis in homes of 609 acute lymphoblastic leukemia (ALL) cases, 89 acute myeloid leukemia (AML) cases, and 893 matched controls participating in the California Childhood Leukemia Study (1995-2008). We used multivariable logistic regression to estimate the risk of ALL and AML associated with six remodeling activities: construction, painting, recarpeting, reflooring, roofing, and weatherproofing. Models were adjusted for age, sex, Hispanic ethnicity, race, household annual income, and residential mobility. RESULTS: Construction in the home between birth and diagnosis was associated with a significant increase in ALL risk (odds ratio [OR]: 1.52, 95% confidence interval [CI]: 1.14-2.02) and a nonsignificant increase in AML risk (OR: 1.75, 95% CI: 0.98-3.15). No other remodeling activities were associated with ALL or AML risk in the main analysis. When stratifying by Hispanic ethnicity, a positive relationship between ALL risk and painting was evident in Hispanic children (OR: 1.47, 95% CI: 1.04-2.07). CONCLUSIONS: Specific home remodeling activities appeared to be associated with increased risk of childhood ALL.
PURPOSE: We investigated the relationship between the risk of childhood leukemia and home remodeling, a surrogate for indoor chemical exposures. METHODS: We collected information on remodeling activities carried out between birth and diagnosis in homes of 609 acute lymphoblastic leukemia (ALL) cases, 89 acute myeloid leukemia (AML) cases, and 893 matched controls participating in the California Childhood Leukemia Study (1995-2008). We used multivariable logistic regression to estimate the risk of ALL and AML associated with six remodeling activities: construction, painting, recarpeting, reflooring, roofing, and weatherproofing. Models were adjusted for age, sex, Hispanic ethnicity, race, household annual income, and residential mobility. RESULTS: Construction in the home between birth and diagnosis was associated with a significant increase in ALL risk (odds ratio [OR]: 1.52, 95% confidence interval [CI]: 1.14-2.02) and a nonsignificant increase in AML risk (OR: 1.75, 95% CI: 0.98-3.15). No other remodeling activities were associated with ALL or AML risk in the main analysis. When stratifying by Hispanic ethnicity, a positive relationship between ALL risk and painting was evident in Hispanic children (OR: 1.47, 95% CI: 1.04-2.07). CONCLUSIONS: Specific home remodeling activities appeared to be associated with increased risk of childhood ALL.
Authors: Mary H Ward; Joanne S Colt; Catherine Metayer; Robert B Gunier; Jay Lubin; Vonda Crouse; Marcia G Nishioka; Peggy Reynolds; Patricia A Buffler Journal: Environ Health Perspect Date: 2009-01-27 Impact factor: 9.031
Authors: John W Roberts; Lance A Wallace; David E Camann; Philip Dickey; Steven G Gilbert; Robert G Lewis; Tim K Takaro Journal: Rev Environ Contam Toxicol Date: 2009 Impact factor: 7.563
Authors: Mary H Ward; Joanne S Colt; Nicole C Deziel; Todd P Whitehead; Peggy Reynolds; Robert B Gunier; Marcia Nishioka; Gary V Dahl; Stephen M Rappaport; Patricia A Buffler; Catherine Metayer Journal: Environ Health Perspect Date: 2014-06-03 Impact factor: 9.031