George Uchenna Eleje1,2, Emeka Stephen Edokwe3,4, Joseph Ifeanyichukwu Ikechebelu1,2,4, Chinyere Ukamaka Onubogu3,4, Ebele Francesca Ugochukwu3,4, Princeston Chukwuemeka Okam2, Adaobi Maryann Ibekwe5. 1. a Effective Care Research Unit, Department of Obstetrics and Gynecology , Nnamdi Azikiwe University , Nnewi , Nigeria. 2. b Department of Obstetrics and Gynecology , Nnamdi Azikiwe University Teaching Hospital , Nnewi , Nigeria. 3. c Paediatrics Infectious Disease and Neonatology Unit , Nnamdi Azikiwe University Teaching Hospital , Nnewi , Nigeria. 4. d PMTCT Unit , Nnamdi Azikiwe University Teaching Hospital , Nnewi , Nigeria. 5. e Antenatal Care Unit , Nnamdi Azikiwe University Teaching Hospital , Nnewi , Nigeria.
Abstract
PURPOSE: To determine mother-to-child transmission (MTCT) rate and associated risk factors of human immune-deficiency virus (HIV) among HIV-infected pregnant women with term premature rupture of membranes (PROM) in comparison with those without PROM at term. MATERIALS AND METHODS: All optimally managed HIV-positive pregnant women of Nnamdi Azikiwe University Teaching Hospital, on highly active anti-retroviral therapy (HAART) who had PROM at term were enrolled. Maternal HIV-1 viral load was not assessed. Follow up was for a minimum of 18 months for evidence of HIV infection. RESULTS: Of the 121 women with PROM at term, 46 (38.0%) were HIV sero-positive, 22/46 (47.8%) of which had their babies followed up till 18 months. The mean latency period was 10.5 ± 5.3 h in PROM group. Apart from duration of PROM (OR = 0.01; 95%CI = 0.00-0.13; p < 0.001), there were no differences in risk factors seen between cases and controls (p > 0.05). Of the 22 (47.8%) babies followed-up in the PROM group and 13 in non-PROM group, none tested positive to HIV, given an MTCT rate of 0%. CONCLUSIONS: MTCT rate was 0% following term PROM and in women without PROM. Since maternal HIV-1 viral load was not assessed, we need to be critical while interpreting the findings.
PURPOSE: To determine mother-to-child transmission (MTCT) rate and associated risk factors of humanimmune-deficiency virus (HIV) among HIV-infected pregnant women with term premature rupture of membranes (PROM) in comparison with those without PROM at term. MATERIALS AND METHODS: All optimally managed HIV-positive pregnant women of Nnamdi Azikiwe University Teaching Hospital, on highly active anti-retroviral therapy (HAART) who had PROM at term were enrolled. Maternal HIV-1 viral load was not assessed. Follow up was for a minimum of 18 months for evidence of HIV infection. RESULTS: Of the 121 women with PROM at term, 46 (38.0%) were HIV sero-positive, 22/46 (47.8%) of which had their babies followed up till 18 months. The mean latency period was 10.5 ± 5.3 h in PROM group. Apart from duration of PROM (OR = 0.01; 95%CI = 0.00-0.13; p < 0.001), there were no differences in risk factors seen between cases and controls (p > 0.05). Of the 22 (47.8%) babies followed-up in the PROM group and 13 in non-PROM group, none tested positive to HIV, given an MTCT rate of 0%. CONCLUSIONS: MTCT rate was 0% following term PROM and in women without PROM. Since maternal HIV-1 viral load was not assessed, we need to be critical while interpreting the findings.
Entities:
Keywords:
HAART; MTCT of HIV; PROM; rupture of membranes