Christos Perisanidis1. 1. Department of Cranio-, Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria christos.perisanidis@meduniwien.ac.at.
Abstract
BACKGROUND: Mutations in the epidermal growth factor receptor (EGFR) tyrosine kinase domain (TKD) are associated with response and resistance to targeted therapy. The EGFR mutation status in patients with advanced oral and oropharyngeal squamous cell carcinoma (OOSCC) was evaluated. A systematic literature review was undertaken to summarize current evidence and estimate the overall prevalence of EGFR TKD mutations in patients with head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Genomic DNA was extracted from formalin-fixed, paraffin-embedded tumor samples of 113 patients with OOSCC. Pyrosequencing was performed to investigate mutations in EGFR exons 18 to 21. Medline databases were searched for relevant studies. Studies reporting mutations in the EGFR TKD in HNSCC were eligible for inclusion in the systematic review. RESULTS: No mutations in the EGFR TKD were observed in 113 samples of OOSCC. A total of 53 eligible studies were included in the systematic review. In total, from the review, 117 patients harboring a total of 159 EGFR TKD mutations were reported among 4122 patients with HNSCC. The overall prevalence of EGFR TKD mutations in HNSCC was 2.8%. CONCLUSION: Large-scale studies are warranted to provide further evidence regarding the mutation status of EGFR in patients with HNSCC. Copyright
BACKGROUND: Mutations in the epidermal growth factor receptor (EGFR) tyrosine kinase domain (TKD) are associated with response and resistance to targeted therapy. The EGFR mutation status in patients with advanced oral and oropharyngeal squamous cell carcinoma (OOSCC) was evaluated. A systematic literature review was undertaken to summarize current evidence and estimate the overall prevalence of EGFR TKD mutations in patients with head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Genomic DNA was extracted from formalin-fixed, paraffin-embedded tumor samples of 113 patients with OOSCC. Pyrosequencing was performed to investigate mutations in EGFR exons 18 to 21. Medline databases were searched for relevant studies. Studies reporting mutations in the EGFR TKD in HNSCC were eligible for inclusion in the systematic review. RESULTS: No mutations in the EGFR TKD were observed in 113 samples of OOSCC. A total of 53 eligible studies were included in the systematic review. In total, from the review, 117 patients harboring a total of 159 EGFR TKD mutations were reported among 4122 patients with HNSCC. The overall prevalence of EGFR TKD mutations in HNSCC was 2.8%. CONCLUSION: Large-scale studies are warranted to provide further evidence regarding the mutation status of EGFR in patients with HNSCC. Copyright
Authors: Curtis R Pickering; Jiexin Zhang; David M Neskey; Mei Zhao; Samar A Jasser; Jiping Wang; Alexandra Ward; C Jillian Tsai; Marcus V Ortega Alves; Jane H Zhou; Jennifer Drummond; Adel K El-Naggar; Richard Gibbs; John N Weinstein; David A Wheeler; Jing Wang; Mitchell J Frederick; Jeffrey N Myers Journal: Clin Cancer Res Date: 2014-05-29 Impact factor: 12.531
Authors: Denis Soulieres; Neil N Senzer; Everett E Vokes; Manuel Hidalgo; Sanjiv S Agarwala; Lillian L Siu Journal: J Clin Oncol Date: 2004-01-01 Impact factor: 44.544
Authors: Daria A Gaykalova; Elizabeth Mambo; Ashish Choudhary; Jeffery Houghton; Kalyan Buddavarapu; Tiffany Sanford; Will Darden; Alex Adai; Andrew Hadd; Gary Latham; Ludmila V Danilova; Justin Bishop; Ryan J Li; William H Westra; Patrick Hennessey; Wayne M Koch; Michael F Ochs; Joseph A Califano; Wenyue Sun Journal: PLoS One Date: 2014-03-25 Impact factor: 3.240
Authors: Shilpa Bhatia; Jaspreet Sharma; Sanjana Bukkapatnam; Ayman Oweida; Shelby Lennon; Andy Phan; Dallin Milner; Nomin Uyanga; Antonio Jimeno; David Raben; Hilary Somerset; Lynn Heasley; Sana D Karam Journal: Clin Cancer Res Date: 2018-05-30 Impact factor: 12.531
Authors: Miguel Ángel González-Moles; Saman Warnakulasuriya; María López-Ansio; Pablo Ramos-García Journal: Cancers (Basel) Date: 2022-08-08 Impact factor: 6.575
Authors: Madelyn Espinosa-Cotton; Elana J Fertig; Laura P Stabile; Autumn Gaither-Davis; Julie E Bauman; Sandra Schmitz; Katherine N Gibson-Corley; Yinwen Cheng; Isaac J Jensen; Vladimir P Badovinac; Douglas Laux; Andrean L Simons Journal: Biomark Res Date: 2019-07-16