Andrea Vodermaier1, Sarah Lucas2, Wolfgang Linden3, Robert Olson4. 1. University of British Columbia, Vancouver, British Columbia, Canada; Department of Obstetrics and Gynecology-Campus Groβhadern, University of Munich, Germany. 2. Radiation Therapy Program, BC Cancer Agency, Vancouver, British Columbia, Canada. 3. University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: wlinden@psych.ubc.ca. 4. University of British Columbia, Vancouver, British Columbia, Canada; Radiation Therapy Program, BC Cancer Agency, Centre for the North, Prince George, British Columbia, Canada.
Abstract
CONTEXT: The question as to whether anxiety and depression are related to mortality in patients with lung cancer is inconclusive. OBJECTIVES: Therefore, the present study is examining associations of anxiety and depression in a large representative sample of patients with Stage III non-small cell lung cancer. METHODS: Patients (n = 684) were routinely assessed for anxiety and depression with the PsychoSocial Screen for Cancer questionnaire after diagnosis of lung cancer and before treatment initiation between 2004 and 2010. Survival data were retrieved in May 2012. Cox proportional hazards regression analyses had been used as statistical procedures allowing adjustment for demographic, biomedical, and treatment variables. RESULTS: In analyses controlling for demographic, biomedical, and treatment prognosticators, anxiety but not depression was associated with increased lung cancer-specific (hazard ratio 1.04; 95% confidence interval 1.01-1.07; P = 0.035) and all-cause (hazard ratio 1.04; 95% confidence interval 1.01-1.07; P = 0.005) mortality. Secondary analyses revealed a confounder effect of performance status on the association between depression and mortality, such that the removal of performance status identified a significant relationship of depression on lung cancer-specific and all-cause mortality. CONCLUSION: In a large population-based sample of patients with non-small cell lung cancer analyses demonstrated associations of anxiety with mortality, adding to the evidence that psychosocial factors might play a role in disease progression in this patient group. Because emotional distress is associated with continued smoking and lack of success of smoking cessation attempts, psychological interventions potentially could influence length of survival in lung cancer patients.
CONTEXT: The question as to whether anxiety and depression are related to mortality in patients with lung cancer is inconclusive. OBJECTIVES: Therefore, the present study is examining associations of anxiety and depression in a large representative sample of patients with Stage III non-small cell lung cancer. METHODS:Patients (n = 684) were routinely assessed for anxiety and depression with the PsychoSocial Screen for Cancer questionnaire after diagnosis of lung cancer and before treatment initiation between 2004 and 2010. Survival data were retrieved in May 2012. Cox proportional hazards regression analyses had been used as statistical procedures allowing adjustment for demographic, biomedical, and treatment variables. RESULTS: In analyses controlling for demographic, biomedical, and treatment prognosticators, anxiety but not depression was associated with increased lung cancer-specific (hazard ratio 1.04; 95% confidence interval 1.01-1.07; P = 0.035) and all-cause (hazard ratio 1.04; 95% confidence interval 1.01-1.07; P = 0.005) mortality. Secondary analyses revealed a confounder effect of performance status on the association between depression and mortality, such that the removal of performance status identified a significant relationship of depression on lung cancer-specific and all-cause mortality. CONCLUSION: In a large population-based sample of patients with non-small cell lung cancer analyses demonstrated associations of anxiety with mortality, adding to the evidence that psychosocial factors might play a role in disease progression in this patient group. Because emotional distress is associated with continued smoking and lack of success of smoking cessation attempts, psychological interventions potentially could influence length of survival in lung cancerpatients.
Authors: O P Geerse; D Brandenbarg; H A M Kerstjens; A J Berendsen; S F A Duijts; H Burger; G A Holtman; J E H M Hoekstra-Weebers; T J N Hiltermann Journal: Lung Cancer Date: 2019-02-10 Impact factor: 5.705
Authors: Carolyn J Presley; Nicole A Arrato; Sarah Janse; Peter G Shields; David P Carbone; Melisa L Wong; Ling Han; Thomas M Gill; Heather G Allore; Barbara L Andersen Journal: JCO Oncol Pract Date: 2021-05-03
Authors: M Jane Bates; Treza Mphwatiwa; Jane Ardrey; Nicola Desmond; Louis W Niessen; S Bertel Squire Journal: PLoS One Date: 2018-08-22 Impact factor: 3.240
Authors: Maria Ines Pinto-Sanchez; Shannon Gadowsky; Suzan McKenzie; Michael J Raphael; Anne Childs; Marroon Thabane; Suzanne Hansen; John K Marshall; David Armstrong Journal: J Can Assoc Gastroenterol Date: 2018-08-10