Cristian Donos1, Ioana Mîndruţă2, Mihai Dragoş Malîia3, Alin Raşină4, Jean Ciurea4, Andrei Barborica5. 1. Physics Department, University of Bucharest, Str. Atomistilor 405, Magurele, Jud. Ilfov CP MG-11, Bucharest-Magurele, Romania; Epilepsy Center, University Hospital of Freiburg, Breisacher Str. 64, Freiburg, Germany. 2. Neurology Department, University Emergency Hospital, Splaiul Independentei 169, Bucharest, Romania; Neurology Department, Carol Davila University of Medicine and Pharmacy, Blvd. Eroii Sanitari 8, Bucharest, Romania. 3. Neurology Department, University Emergency Hospital, Splaiul Independentei 169, Bucharest, Romania. 4. Department of Neurosurgery, Bagdasar-Arseni Emergency Hospital, Şos. Berceni 12, Bucharest, Romania. 5. Physics Department, University of Bucharest, Str. Atomistilor 405, Magurele, Jud. Ilfov CP MG-11, Bucharest-Magurele, Romania; FHC Inc, 1201 Main St, Bowdoin, ME, USA. Electronic address: andrei.barborica@fizica.unibuc.ro.
Abstract
OBJECTIVE: To perform a side-by-side comparison of two epileptogenicity biomarkers, high frequency oscillations (HFOs) and delayed responses (DRs), as a result of single-pulse electrical stimulation. METHODS: We have recorded stimulation-evoked HFOs and DRs in 16 epileptic patients undergoing presurgical evaluation using the stereoelectroencephalographic method. To evaluate converging and complementary information provided by the biomarkers, we analyzed them individually and for logical "and"/"or" combinations between them. 3D maps of the biomarkers' distributions by recording location (inbound maps) and by stimulation location (outbound maps) were created to analyze their relationship with the epileptogenic structures. RESULTS: HFOs occur less frequently than DRs, by 18.7%, when counting by recording contacts, and more frequently, by 7.4%, when counting by stimulation contacts. 40.6% of the contacts exhibiting HFOs also exhibit DRs, and 44.1% of the contacts exhibiting DRs also exhibit HFOs. When combining biomarkers, there was a tradeoff between increased seizure onset zone (SOZ) sensitivity, from 21.3% to 73%, and decreased specificity, from 87.2% to 34.3%. CONCLUSIONS: There is a moderate similarity in the information provided by the DRs and HFOs. SIGNIFICANCE: The biomarkers complement each other, but there is a tradeoff between different metrics for SOZ localization.
OBJECTIVE: To perform a side-by-side comparison of two epileptogenicity biomarkers, high frequency oscillations (HFOs) and delayed responses (DRs), as a result of single-pulse electrical stimulation. METHODS: We have recorded stimulation-evoked HFOs and DRs in 16 epilepticpatients undergoing presurgical evaluation using the stereoelectroencephalographic method. To evaluate converging and complementary information provided by the biomarkers, we analyzed them individually and for logical "and"/"or" combinations between them. 3D maps of the biomarkers' distributions by recording location (inbound maps) and by stimulation location (outbound maps) were created to analyze their relationship with the epileptogenic structures. RESULTS: HFOs occur less frequently than DRs, by 18.7%, when counting by recording contacts, and more frequently, by 7.4%, when counting by stimulation contacts. 40.6% of the contacts exhibiting HFOs also exhibit DRs, and 44.1% of the contacts exhibiting DRs also exhibit HFOs. When combining biomarkers, there was a tradeoff between increased seizure onset zone (SOZ) sensitivity, from 21.3% to 73%, and decreased specificity, from 87.2% to 34.3%. CONCLUSIONS: There is a moderate similarity in the information provided by the DRs and HFOs. SIGNIFICANCE: The biomarkers complement each other, but there is a tradeoff between different metrics for SOZ localization.
Authors: Golnoosh Kamali; Rachel June Smith; Mark Hays; Christopher Coogan; Nathan E Crone; Joon Y Kang; Sridevi V Sarma Journal: Front Neurol Date: 2020-12-10 Impact factor: 4.003
Authors: Jean-Didier Lemaréchal; Maciej Jedynak; Lena Trebaul; Anthony Boyer; François Tadel; Manik Bhattacharjee; Pierre Deman; Viateur Tuyisenge; Leila Ayoubian; Etienne Hugues; Blandine Chanteloup-Forêt; Carole Saubat; Raouf Zouglech; Gina Catalina Reyes Mejia; Sébastien Tourbier; Patric Hagmann; Claude Adam; Carmen Barba; Fabrice Bartolomei; Thomas Blauwblomme; Jonathan Curot; François Dubeau; Stefano Francione; Mercedes Garcés; Edouard Hirsch; Elizabeth Landré; Sinclair Liu; Louis Maillard; Eeva-Liisa Metsähonkala; Ioana Mindruta; Anca Nica; Martin Pail; Ana Maria Petrescu; Sylvain Rheims; Rodrigo Rocamora; Andreas Schulze-Bonhage; William Szurhaj; Delphine Taussig; Antonio Valentin; Haixiang Wang; Philippe Kahane; Nathalie George; Olivier David Journal: Brain Date: 2022-06-03 Impact factor: 15.255