Literature DB >> 28063768

Emerging Role for Mammalian Target of Rapamycin in Male Fertility.

Pedro F Oliveira1, C Y Cheng2, Marco G Alves3.   

Abstract

Male fertility is modulated by environmental, endocrine, paracrine, and metabolic cues. Mammalian target of rapamycin (mTOR) coordinates many cellular events in response to those signals. Here, we discuss how the mTOR pathway integrates and mediates signals throughout the male reproductive system, acting as a central player in the control of spermatogenesis.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Sertoli cell; fertility; mTOR; spermatogenesis

Mesh：

Substances：

Year:  2017        PMID： 28063768      PMCID： PMC5499664          DOI： 10.1016/j.tem.2016.12.004

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  15 in total

1.  Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells.

Authors:  Tito T Jesus; Pedro F Oliveira; Joaquina Silva; Alberto Barros; Rita Ferreira; Mário Sousa; C Yan Cheng; Branca M Silva; Marco G Alves
Journal:  Fertil Steril       Date:  2015-12-14       Impact factor: 7.329

2.  Rapamycin (Sirolimus) alters mechanistic target of rapamycin pathway regulation and microRNA expression in mouse meiotic spermatocytes.

Authors:  A Mukherjee; S Koli; K V R Reddy
Journal:  Andrology       Date:  2015-09       Impact factor: 3.842

3.  Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo.

Authors:  Jonathan T Busada; Bryan A Niedenberger; Ellen K Velte; Brett D Keiper; Christopher B Geyer
Journal:  Dev Biol       Date:  2015-08-05       Impact factor: 3.582

4.  Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network.

Authors:  Ka-Wai Mok; Dolores D Mruk; Will M Lee; C Yan Cheng
Journal:  FASEB J       Date:  2013-01-03       Impact factor: 5.191

5.  Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis.

Authors:  Yanyan Gao; Xiufeng Bai; Dejiu Zhang; Chunsheng Han; Jing Yuan; Wenbin Liu; Xintao Cao; Zilei Chen; Fugen Shangguan; Zhenyuan Zhu; Fei Gao; Yan Qin
Journal:  Nat Struct Mol Biol       Date:  2016-04-11       Impact factor: 15.369

6.  rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9.

Authors:  Ka-Wai Mok; Dolores D Mruk; C Yan Cheng
Journal:  J Cell Sci       Date:  2014-09-12       Impact factor: 5.285

7.  Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.

Authors:  Pradeep S Tanwar; Tomoko Kaneko-Tarui; LiHua Zhang; Jose M Teixeira
Journal:  Hum Mol Genet       Date:  2012-07-12       Impact factor: 6.150

8.  Sirolimus-associated infertility: case report and literature review of possible mechanisms.

Authors:  M A Deutsch; I Kaczmarek; S Huber; D Schmauss; A Beiras-Fernandez; M Schmoeckel; R Ochsenkuehn; B Meiser; J Mueller-Hoecker; B Reichart; B Bruno Reichart
Journal:  Am J Transplant       Date:  2007-10       Impact factor: 8.086

9.  The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility.

Authors:  Christoph Schell; Oliver Kretz; Wei Liang; Betina Kiefer; Simon Schneider; Dominik Sellung; Tillmann Bork; Christian Leiber; Markus A Rüegg; Con Mallidis; Stefan Schlatt; Artur Mayerhofer; Tobias B Huber; Florian Grahammer
Journal:  Am J Pathol       Date:  2015-12-10       Impact factor: 4.307

10.  mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice.

Authors:  Alexandre Boyer; Meggie Girard; Dayananda S Thimmanahalli; Adrien Levasseur; Christophe Céleste; Marilène Paquet; Rajesha Duggavathi; Derek Boerboom
Journal:  Biol Reprod       Date:  2016-06-08       Impact factor: 4.285
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  14 in total

1.  Mechanistic target of rapamycin (mTOR) implicated in plasticity of the reproductive axis during social status transitions.

Authors:  Karen P Maruska; Young Chang Sohn; Russell D Fernald
Journal:  Gen Comp Endocrinol       Date:  2019-06-18       Impact factor: 2.822

2.  mTORC1/rpS6 regulates blood-testis barrier dynamics and spermatogenetic function in the testis in vivo.

Authors:  Stephen Y T Li; Ming Yan; Haiqi Chen; Tito Jesus; Will M Lee; Xiang Xiao; C Yan Cheng
Journal:  Am J Physiol Endocrinol Metab       Date:  2017-10-31       Impact factor: 4.310

3.  The Activated AMPK/mTORC2 Signaling Pathway Associated with Oxidative Stress in Seminal Plasma Contributes to Idiopathic Asthenozoospermia.

Authors:  Nannan Cao; Chunhui Hu; Bintong Xia; Yan He; Jiaolong Huang; Zhicheng Yuan; Jie Deng; Peng Duan
Journal:  Oxid Med Cell Longev       Date:  2022-06-08       Impact factor: 7.310

4.  Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells.

Authors:  Di Wu; Chun-Jie Huang; Xiao-Fei Jiao; Zhi-Ming Ding; Jia-Yu Zhang; Fan Chen; Yong-Sheng Wang; Xiang Li; Li-Jun Huo
Journal:  Oncotarget       Date:  2017-08-16

5.  Interference with lactate metabolism by mmu-miR-320-3p via negatively regulating GLUT3 signaling in mouse Sertoli cells.

Authors:  Li-Li Zhang; Jing Ma; Bo Yang; Jie Zhao; Bin-Yuan Yan; Yuan-Qiang Zhang; Wei Li
Journal:  Cell Death Dis       Date:  2018-09-20       Impact factor: 8.469

6.  Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa.

Authors:  Marina G Yefimova; Antoine Buschiazzo; Agnes Burel; Marie-Therese Lavault; Celine Pimentel; Guilhem Jouve; Sylvie Jaillard; Bernard Jegou; Nicolas Bourmeyster; Celia Ravel
Journal:  Asian J Androl       Date:  2019 Nov-Dec       Impact factor: 3.285

7.  Dysregulation of Key Proteins Associated with Sperm Motility and Fertility Potential in Cancer Patients.

Authors:  Manesh Kumar Panner Selvam; Renata Finelli; Saradha Baskaran; Ashok Agarwal
Journal:  Int J Mol Sci       Date:  2020-09-15       Impact factor: 5.923

8.  Uropathogenic Escherichia coli Infection Compromises the Blood-Testis Barrier by Disturbing mTORC1-mTORC2 Balance.

Authors:  Yongning Lu; Miao Liu; Nicholas J Tursi; Bin Yan; Xiang Cao; Qi Che; Nianqin Yang; Xi Dong
Journal:  Front Immunol       Date:  2021-02-19       Impact factor: 7.561

Review 9.  Metabolic diseases affect male reproduction and induce signatures in gametes that may compromise the offspring health.

Authors:  Sara C Pereira; Luís Crisóstomo; Mário Sousa; Pedro F Oliveira; Marco G Alves
Journal:  Environ Epigenet       Date:  2020-12-08

10.  Characterization and functional roles of paternal RNAs in 2-4 cell bovine embryos.

Authors:  Nicole Gross; Maria Giuseppina Strillacci; Francisco Peñagaricano; Hasan Khatib
Journal:  Sci Rep       Date:  2019-12-30       Impact factor: 4.379
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