Alessio Molfino1, Maria Ida Amabile2, Thomas Ammann3, Alessio Farcomeni4, Luana Lionetto5, Maurizio Simmaco6, Silvia Lai2, Alessandro Laviano2, Filippo Rossi Fanelli2, Maria Grazia Chiappini3, Maurizio Muscaritoli2. 1. Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy. Electronic address: alessio.molfino@uniroma1.it. 2. Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy. 3. Hemodialysis Unit, Fatebenefratelli 'Isola Tiberina' Hospital, Rome, Italy. 4. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. 5. Personalized Medicine Unit, Istituto Dermopatico dell'Immacolata-IRCCS, Rome, Italy. 6. Neuroscience, Mental Health and Sense Organs Department, Advanced Molecular Diagnostics Unit, Sant'Andrea Hospital, Rome, Italy.
Abstract
OBJECTIVE: Physical inactivity is frequent in patients on hemodialysis (HD), and represents a reliable predictor of morbidity and mortality. Beta-aminoisobutyric acid (BAIBA) is a contraction-induced myokine, the plasma levels of which increase with exercise and are inversely associated with metabolic risk factors. The aim of this study was to ascertain whether physical inactivity and clinical parameters relate to plasma BAIBA levels in this patient population. METHODS: Adult patients on HD were included, and the presence of physical inactivity was assessed. BAIBA levels were measured in these patients and in healthy individuals. We assessed barriers to physical activity, including 23 items regarding psychophysical and financial barriers. Body composition was assessed by bioimpedance and muscle strength by handgrip dynamometer. Nonparametric tests and logistic regression analyses were performed. RESULTS: Forty-nine patients on HD were studied; 49% were physically active and 51% were inactive. Of the patients, 43 reported barriers to physical activity and 61% of inactive patients reported three or more barriers. BAIBA levels were lower in patients on HD with respect to controls (P < 0.001). Stratifying HD patients as active and inactive, both groups showed significantly lower BAIBA levels versus controls (P = 0.0005, P < 0.001, respectively). Nondiabetic patients on HD showed increased BAIBA levels compared with diabetic patients (P < 0.001). Patients on HD endorsing the two most frequent barriers showed lower BAIBA levels than those not reporting these barriers (P = 0.006). Active patients showed higher intracellular water (%) (P = 0.008), and active and inactive patients showed significant correlation between total body muscle mass and handgrip strength (P = 0.04, P = 0.005, respectively). CONCLUSIONS: Physical inactivity is highly prevalent among patients on HD and BAIBA correlates with barriers to physical activity reported by inactive patients.
OBJECTIVE: Physical inactivity is frequent in patients on hemodialysis (HD), and represents a reliable predictor of morbidity and mortality. Beta-aminoisobutyric acid (BAIBA) is a contraction-induced myokine, the plasma levels of which increase with exercise and are inversely associated with metabolic risk factors. The aim of this study was to ascertain whether physical inactivity and clinical parameters relate to plasma BAIBA levels in this patient population. METHODS: Adult patients on HD were included, and the presence of physical inactivity was assessed. BAIBA levels were measured in these patients and in healthy individuals. We assessed barriers to physical activity, including 23 items regarding psychophysical and financial barriers. Body composition was assessed by bioimpedance and muscle strength by handgrip dynamometer. Nonparametric tests and logistic regression analyses were performed. RESULTS: Forty-nine patients on HD were studied; 49% were physically active and 51% were inactive. Of the patients, 43 reported barriers to physical activity and 61% of inactive patients reported three or more barriers. BAIBA levels were lower in patients on HD with respect to controls (P < 0.001). Stratifying HDpatients as active and inactive, both groups showed significantly lower BAIBA levels versus controls (P = 0.0005, P < 0.001, respectively). Nondiabeticpatients on HD showed increased BAIBA levels compared with diabeticpatients (P < 0.001). Patients on HD endorsing the two most frequent barriers showed lower BAIBA levels than those not reporting these barriers (P = 0.006). Active patients showed higher intracellular water (%) (P = 0.008), and active and inactive patients showed significant correlation between total body muscle mass and handgrip strength (P = 0.04, P = 0.005, respectively). CONCLUSIONS: Physical inactivity is highly prevalent among patients on HD and BAIBA correlates with barriers to physical activity reported by inactive patients.
Authors: Zhiying Wang; Liangqiao Bian; Chenglin Mo; Hui Shen; Lan Juan Zhao; Kuan-Jui Su; Maciej Kukula; Jauh Tzuoh Lee; Daniel W Armstrong; Robert Recker; Joan Lappe; Lynda F Bonewald; Hong-Wen Deng; Marco Brotto Journal: Commun Biol Date: 2020-01-22