| Literature DB >> 28063056 |
Nazira J Albargothy1, Matthew MacGregor Sharp1, Maureen Gatherer1, Alan Morris1, Roy O Weller1, Cheryl Hawkes2, Roxana O Carare3.
Abstract
In this chapter we describe in detail the surgical and imaging techniques employed for the study of the anatomical routes of drainage of cerebrospinal fluid (CSF) and interstitial fluid (ISF) from the brain. The types of tracers, sites of injection, and volumes injected are crucial. For example, when testing the drainage of ISF from the parenchyma, volumes larger than 0.5 μL result in spillage of ISF into the ventricular CSF.Entities:
Keywords: Alzheimer’s disease; Cerebrospinal fluid; Cisterna magna injections; Interstitial fluid; Intraparenchymal stereotactic injections; Mouse brain; Perivascular lymphatic drainage; Rodent perfusion; Solute clearance
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Year: 2017 PMID： 28063056 DOI： 10.1007/978-1-4939-6786-5_24
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745