| Literature DB >> 28063053 |
Sylvia Brugman1, Edward E S Nieuwenhuis2.
Abstract
Zebrafish are an excellent model for the study of intestinal immunity. The availability of several transgenic reporter fish for different innate and adaptive immune cells and the high homology in terms of gut function and morphology enables in depth analysis of the process of intestinal inflammation. Here, we describe a method to induce intestinal inflammation by intra-rectal injection of the hapten oxazolone in adult zebrafish.Entities:
Keywords: Crohn’s disease; Granulocytes; Gut barrier function; IBD; Intestinal inflammation; Intra-rectal injection; Oxazolone; Ulcerative colitis; Zebrafish
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Year: 2017 PMID： 28063053 DOI： 10.1007/978-1-4939-6786-5_21
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745