Jérémie Pourchez1, Fabien de Oliveira2, Sophie Perinel-Ragey3, Thierry Basset4, Jean-Michel Vergnon5, Nathalie Prévôt2. 1. Ecole Nationale Supérieure des Mines de Saint-Etienne, CIS-EMSE, SAINBIOSE, F-42023 Saint Etienne, France; INSERM, U1059, F-42023 Saint Etienne, France; Université de Lyon, F-69000 Lyon, France. Electronic address: pourchez@emse.fr. 2. Ecole Nationale Supérieure des Mines de Saint-Etienne, CIS-EMSE, SAINBIOSE, F-42023 Saint Etienne, France; INSERM, U1059, F-42023 Saint Etienne, France; Université de Lyon, F-69000 Lyon, France; CHU Saint-Etienne, Department of Nuclear Medicine, F-42055 Saint-Etienne, France. 3. INSERM, U1059, F-42023 Saint Etienne, France; Université de Lyon, F-69000 Lyon, France; CHU Saint-Etienne, Medical-Surgical Intensive Care Unit, F-42055 Saint-Etienne, France. 4. INSERM, U1059, F-42023 Saint Etienne, France; Université de Lyon, F-69000 Lyon, France; CHU de Saint-Etienne, Laboratoire de Pharmacologie - Toxicologie, F-42055 Saint-Etienne, France. 5. INSERM, U1059, F-42023 Saint Etienne, France; Université de Lyon, F-69000 Lyon, France; CHU Saint-Etienne, Department of Chest Diseases and Thoracic Oncology, F-42055 Saint-Etienne, France.
Abstract
PURPOSE: A need remains for alternative devices for aerosol drug delivery that are low cost, convenient and easy to use for the patient, but also capable of producing small-sized aerosol particles. This study investigated the potential of recent high power electronic nicotine delivery systems (ENDS) as aerosol generation devices for inhaled bronchodilators. METHODS: The particle size distribution was measured using a cascade impactor. The delivery of terbutaline sulfate, a current bronchodilator used for asthma or COPD therapy by inhalation, was studied. This drug was quantified by liquid chromatography coupled with tandem mass spectrometry. RESULTS: The particle size distribution in terms of mass frequency (in two ways, gravimetrically and quantitatively through drug assay on each stage) and the terbutaline sulfate concentration in the aerosol were elucidated. The mass median aerodynamic diameter (MMAD) and the drug delivery rose when the power level increased, to reach 5.6±0.4μg/puff with a MMAD of 0.78±0.03μm at 25W. CONCLUSION: New generation high-power ENDS are very efficient to generate carrier-droplets in the submicron range containing drug molecules with a constant drug concentration whatever the size-fractions. ENDS appear to be highly patient-adaptive.
PURPOSE: A need remains for alternative devices for aerosol drug delivery that are low cost, convenient and easy to use for the patient, but also capable of producing small-sized aerosol particles. This study investigated the potential of recent high power electronic nicotine delivery systems (ENDS) as aerosol generation devices for inhaled bronchodilators. METHODS: The particle size distribution was measured using a cascade impactor. The delivery of terbutaline sulfate, a current bronchodilator used for asthma or COPD therapy by inhalation, was studied. This drug was quantified by liquid chromatography coupled with tandem mass spectrometry. RESULTS: The particle size distribution in terms of mass frequency (in two ways, gravimetrically and quantitatively through drug assay on each stage) and the terbutaline sulfate concentration in the aerosol were elucidated. The mass median aerodynamic diameter (MMAD) and the drug delivery rose when the power level increased, to reach 5.6±0.4μg/puff with a MMAD of 0.78±0.03μm at 25W. CONCLUSION: New generation high-power ENDS are very efficient to generate carrier-droplets in the submicron range containing drug molecules with a constant drug concentration whatever the size-fractions. ENDS appear to be highly patient-adaptive.
Authors: Cristina Miliano; E Reilly Scott; Laura B Murdaugh; Emma R Gnatowski; Christine L Faunce; Megan S Anderson; Malissa M Reyes; Ann M Gregus; Matthew W Buczynski Journal: J Neurosci Methods Date: 2019-10-12 Impact factor: 2.390
Authors: Haley A Mulder; Jesse L Patterson; Matthew S Halquist; Leon Kosmider; Joseph B McGee Turner; Justin L Poklis; Alphonse Poklis; Michelle R Peace Journal: Sci Rep Date: 2019-07-15 Impact factor: 4.379