Thomas Bogs1, Nadine Zwink2, Vera Chonitzki3, Alice Hölscher4, Thomas M Boemers4, Oliver Münsterer5, Ralf Kurz6, Andreas Heydweiller6, Marcus Pauly7, Andreas Leutner8, Benno M Ure9, Martin Lacher10, Oliver Johannes Deffaa10, Holger Thiele11, Soyhan Bagci1, Ekkehart Jenetzky2,12,13, Johannes Schumacher3, Heiko Reutter1,3. 1. Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany. 2. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany. 3. Institute of Human Genetics, University of Bonn, Bonn, Germany. 4. Department of Pediatric Surgery and Pediatric Urology, Children's Hospital Amsterdamer Strasse, Municipal Hospital of the City of Cologne, Cologne, Germany. 5. Department of Pediatric Surgery, University Hospital Mainz, Mainz, Germany. 6. Department of Pediatric Surgery, University Hospital Bonn, Bonn, Germany. 7. Department of Pediatric Surgery, Asklepios Children's Hospital St. Augustin, St. Augustin, Germany. 8. Department of Pediatric Surgery, Medical Center Dortmund, Dortmund, Germany. 9. Center of Pediatric Surgery, Hannover Medical School, Hannover, Germany. 10. Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany. 11. Cologne Center for Genomics, University of Cologne, Cologne, Germany. 12. Department of Child and Adolescent Psychiatry and Psychotherapy, Johannes-Gutenberg University, Mainz, Germany. 13. Child Center Maulbronn gGmbH, Hospital for Pediatric Neurology and Social Pediatrics, Maulbronn, Germany.
Abstract
BACKGROUND: Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) represents the most common developmental malformation of the upper digestive tract. It is classified into six subtypes according to the classification of Vogt, depending on anatomical variation of this malformation. Around 50% of the patients with EA/TEF present additional anomalies, which often influence, next to the EA/TEF subtype, the overall prognosis of EA/TEF newborns. Here, we investigated the association of the different EA/TEF subtypes with co-occurring congenital anomalies in EA/TEF patients and demonstrate their implications for postnatal diagnostic workup. MATERIALS AND METHODS: We investigated 333 patients of a large German multicenter study born between 1980 and 2012. After evaluation of all available clinical records, 235 patients were included in our analysis. We compared our results with existing data. RESULTS: The highest risk for co-occurring anomalies was seen in patients with most common Vogt 3b (p = 0.024), especially for additional gastrointestinal anomalies (p = 0.04). Co-occurring anomalies of the skin were significantly more common in patients with subtype Vogt 2 (p = 0.024). A significant correlation was observed for an impaired neurodevelopmental outcome and EA/TEF Vogt 3a (p = 0.041). Patients with EA/TEF showed a higher risk to present with any additional congenital anomaly compared with the general population (p < 0.001). CONCLUSION: Our results warrant thorough clinical workup for gastrointestinal anomalies especially in patients with Vogt 3b. Moreover, it might be necessary to focus on a thorough aftercare for neurocognitive development in patients with Vogt 3a. The here presented observations need to be confirmed by future studies. Georg Thieme Verlag KG Stuttgart · New York.
BACKGROUND:Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) represents the most common developmental malformation of the upper digestive tract. It is classified into six subtypes according to the classification of Vogt, depending on anatomical variation of this malformation. Around 50% of the patients with EA/TEF present additional anomalies, which often influence, next to the EA/TEF subtype, the overall prognosis of EA/TEF newborns. Here, we investigated the association of the different EA/TEF subtypes with co-occurring congenital anomalies in EA/TEFpatients and demonstrate their implications for postnatal diagnostic workup. MATERIALS AND METHODS: We investigated 333 patients of a large German multicenter study born between 1980 and 2012. After evaluation of all available clinical records, 235 patients were included in our analysis. We compared our results with existing data. RESULTS: The highest risk for co-occurring anomalies was seen in patients with most common Vogt 3b (p = 0.024), especially for additional gastrointestinal anomalies (p = 0.04). Co-occurring anomalies of the skin were significantly more common in patients with subtype Vogt 2 (p = 0.024). A significant correlation was observed for an impaired neurodevelopmental outcome and EA/TEF Vogt 3a (p = 0.041). Patients with EA/TEF showed a higher risk to present with any additional congenital anomaly compared with the general population (p < 0.001). CONCLUSION: Our results warrant thorough clinical workup for gastrointestinal anomalies especially in patients with Vogt 3b. Moreover, it might be necessary to focus on a thorough aftercare for neurocognitive development in patients with Vogt 3a. The here presented observations need to be confirmed by future studies. Georg Thieme Verlag KG Stuttgart · New York.
Authors: Erwin Brosens; Janine F Felix; Anne Boerema-de Munck; Elisabeth M de Jong; Elisabeth M Lodder; Sigrid Swagemakers; Marjon Buscop-van Kempen; Ronald R de Krijger; Rene M H Wijnen; Wilfred F J van IJcken; Peter van der Spek; Annelies de Klein; Dick Tibboel; Robbert J Rottier Journal: PLoS One Date: 2020-11-17 Impact factor: 3.240