| Literature DB >> 28059797 |
Jamie Toombs1, Martha S Foiani1, Ross W Paterson2, Amanda Heslegrave1, Selina Wray1, Jonathan M Schott2, Nick C Fox2, Michael P Lunn3, Kaj Blennow4, Henrik Zetterberg1,4.
Abstract
The effect of spinal manometers on cerebrospinal fluid (CSF) amyloid-β (Aβ) concentration was investigated. Pooled human CSF samples were divided in two, one half passed through a manometer into a collection tube, the other transferred directly to a collection tube. CSF was analyzed for Aβ38/40/42 using an electrochemiluminescence immunoassay. Relative to control, use of a manometer decreased Aβ38/40/42 concentration by 5.6% (±1.5SE), 4.4% (±1.7SE), and 4.3% (±2.4SE), respectively. The ratios of Aβ42 :40, Aβ42 :38, and Aβ40 :38 were not affected by manometer treatment. Factors which artificially lower CSF Aβ concentrations are relevant to clinical diagnosis for AD and study design.Entities:
Keywords: Alzheimer’s disease; amyloid-β; biomarkers; cerebrospinal fluid; manometer; pre-analytical factor
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Year: 2017 PMID： 28059797 DOI： 10.3233/JAD-161126
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472