Daniel Erskine1,2, Alan J Thomas3, Johannes Attems1, John-Paul Taylor3, Ian G McKeith3, Christopher M Morris1,2, Ahmad A Khundakar1. 1. Institute of Neuroscience, Ageing Research Laboratories, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom. 2. Medical Toxicology Centre, Wolfson Unit of Clinical Pharmacology, Newcastle University, Claremont Place, Newcastle upon Tyne, United Kingdom. 3. Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.
Abstract
BACKGROUND: Complex visual hallucinations occur in 70%-80% of dementia with Lewy bodies patients and significantly affect well-being. Despite the prevalence of visual hallucinations in dementia with Lewy bodies, the neuropathological basis of this phenomenon is poorly understood. The pulvinar nucleus of the thalamus has not previously been neuropathologically examined, but has been linked to visual hallucinations in dementia with Lewy bodies. The objective of this study was to investigate whether neuropathological or morphometric changes occur in the pulvinar nucleus in dementia with Lewy bodies cases that may contribute to visual hallucinations. METHODS: Postmortem pulvinar tissue was acquired from 8 individuals with dementia with Lewy bodies, 8 with Alzheimer's disease, and 8 control cases and was analyzed using stereological and quantitative neuropathological techniques. RESULTS: Lewy body pathology was present throughout the pulvinar in dementia with Lewy bodies but was most severe in the medial pulvinar. Neuronal loss was found in the lateral pulvinar in dementia with Lewy bodies and Alzheimer's disease but was more severe in dementia with Lewy bodies. CONCLUSIONS: The pulvinar has an important role in visual attention, visual target selection and affective visual perception. These functions are thought to be deficient in dementia with Lewy bodies and may contribute a vulnerability to visual hallucinations. Therefore, this study has demonstrated neuropathological changes that may promote the manifestation of visual hallucinations in dementia with Lewy bodies.
BACKGROUND: Complex visual hallucinations occur in 70%-80% of dementia with Lewy bodies patients and significantly affect well-being. Despite the prevalence of visual hallucinations in dementia with Lewy bodies, the neuropathological basis of this phenomenon is poorly understood. The pulvinar nucleus of the thalamus has not previously been neuropathologically examined, but has been linked to visual hallucinations in dementia with Lewy bodies. The objective of this study was to investigate whether neuropathological or morphometric changes occur in the pulvinar nucleus in dementia with Lewy bodies cases that may contribute to visual hallucinations. METHODS: Postmortem pulvinar tissue was acquired from 8 individuals with dementia with Lewy bodies, 8 with Alzheimer's disease, and 8 control cases and was analyzed using stereological and quantitative neuropathological techniques. RESULTS: Lewy body pathology was present throughout the pulvinar in dementia with Lewy bodies but was most severe in the medial pulvinar. Neuronal loss was found in the lateral pulvinar in dementia with Lewy bodies and Alzheimer's disease but was more severe in dementia with Lewy bodies. CONCLUSIONS: The pulvinar has an important role in visual attention, visual target selection and affective visual perception. These functions are thought to be deficient in dementia with Lewy bodies and may contribute a vulnerability to visual hallucinations. Therefore, this study has demonstrated neuropathological changes that may promote the manifestation of visual hallucinations in dementia with Lewy bodies.
Authors: Daniel Erskine; John-Paul Taylor; Alan Thomas; Daniel Collerton; Ian McKeith; Ahmad Khundakar; Johannes Attems; Christopher Morris Journal: Neurosci Bull Date: 2019-02-06 Impact factor: 5.203
Authors: Daniel Erskine; Jinhui Ding; Alan J Thomas; Alice Kaganovich; Ahmad A Khundakar; Peter S Hanson; John-Paul Taylor; Ian G McKeith; Johannes Attems; Mark R Cookson; Christopher M Morris Journal: Mov Disord Date: 2018-03-23 Impact factor: 10.338