Nadim Abo Youssef1, Marc P Schneider1,2,3, Livio Mordasini4, Benjamin V Ineichen2,3, Lucas M Bachmann5, Emmanuel Chartier-Kastler6, Jalesh N Panicker7, Thomas M Kessler1. 1. Neuro-Urology, Spinal Cord Injury Center and Research, Balgrist University Hospital, University of Zürich, Zürich, Switzerland. 2. Brain Research Institute, University of Zürich, Zürich, Switzerland. 3. Department of Health Sciences and Technology, Swiss Federal Institute of Technology Zürich, Zürich, Switzerland. 4. Department of Urology, Cantonal Hospital Lucerne, Lucerne, Switzerland. 5. Medignition Inc., Research Consultants, Zürich, Switzerland. 6. Department of Urology, Academic Hospital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Pierre et Marie Curie Medical School, Sorbonne Universités, Paris 6 University, Paris, France. 7. Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery and UCL Institute of Neurology, London, UK.
Abstract
OBJECTIVES: To review systematically all the available evidence on efficacy and safety of cannabinoids for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS). PATIENTS AND METHODS: The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were identified by electronic search of the Cochrane register, Embase, Medline, Scopus (last search on 11 November 2016). RESULTS: After screening 8 469 articles, we included two randomized controlled trials and one open-label study, in which a total of 426 patients were enrolled. Cannabinoids relevantly decreased the number of incontinence episodes in all three studies. Pooling data showed the mean difference in incontinence episodes per 24 h to be -0.35 (95% confidence interval -0.46 to -0.24). Mild adverse events were frequent (38-100%), but only two patients (0.7%) reported a serious adverse event. CONCLUSIONS: Preliminary data imply that cannabinoids might be an effective and safe treatment option for NLUTD in patients with MS; however, the evidence base is poor and more high-quality, well-designed and adequately powered and sampled studies are urgently needed to reach definitive conclusions.
OBJECTIVES: To review systematically all the available evidence on efficacy and safety of cannabinoids for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS). PATIENTS AND METHODS: The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were identified by electronic search of the Cochrane register, Embase, Medline, Scopus (last search on 11 November 2016). RESULTS: After screening 8 469 articles, we included two randomized controlled trials and one open-label study, in which a total of 426 patients were enrolled. Cannabinoids relevantly decreased the number of incontinence episodes in all three studies. Pooling data showed the mean difference in incontinence episodes per 24 h to be -0.35 (95% confidence interval -0.46 to -0.24). Mild adverse events were frequent (38-100%), but only two patients (0.7%) reported a serious adverse event. CONCLUSIONS: Preliminary data imply that cannabinoids might be an effective and safe treatment option for NLUTD in patients with MS; however, the evidence base is poor and more high-quality, well-designed and adequately powered and sampled studies are urgently needed to reach definitive conclusions.
Authors: Morteza Abyadeh; Vivek Gupta; Joao A Paulo; Veer Gupta; Nitin Chitranshi; Angela Godinez; Danit Saks; Mafruha Hasan; Ardeshir Amirkhani; Matthew McKay; Ghasem H Salekdeh; Paul A Haynes; Stuart L Graham; Mehdi Mirzaei Journal: Biomolecules Date: 2021-09-27
Authors: Jane Louisa Debus; Paula Bachmann; Niklas Frahm; Pegah Mashhadiakbar; Silvan Elias Langhorst; Barbara Streckenbach; Julia Baldt; Felicita Heidler; Michael Hecker; Uwe Klaus Zettl Journal: Ther Adv Chronic Dis Date: 2022-08-04 Impact factor: 4.970