Uttam Kumar1, Amit Arya2, Vivek Agarwal2. 1. Centre of Biomedical Research, Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Lucknow, India. Electronic address: dr.uttam.kumar@gmail.com. 2. Department of Psychiatry, King George Medical University, Lucknow, India.
Abstract
PURPOSE: Neuroimaging studies provide vital information related to the neurobiology of ADHD, but there still exists a wide gap in relevant information. The present study aimed to elucidate the neuroanatomical alteration in Attention deficit hyperactivity disorder (ADHD) children/adolescents. METHODS: Voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) was performed to examine neuroanatomic distinctions in 18 children/adolescents aged 7.5-13years diagnosed with DSM-IV TR as ADHD (non-medicated). They were compared with 18 healthy matched controls. RESULTS: VBCT findings in ADHD children/adolescents revealed reduced cortical thickness in the left superior frontal, left orbito-frontal and left dorsal anterior cingulate cortex. VBM findings confirmed decreased gray matter volume in the left orbito frontal, left middle frontal/dorsolateral prefrontal, left middle temporal and left cerebellum in comparison to control group. A decrease in white matter volume was also observed in the left inferior frontal and left calcarine of ADHD children/adolescents. CONCLUSION: Results reflect possible abnormal neuroanatomical development patterns in ADHD children.
PURPOSE: Neuroimaging studies provide vital information related to the neurobiology of ADHD, but there still exists a wide gap in relevant information. The present study aimed to elucidate the neuroanatomical alteration in Attention deficit hyperactivity disorder (ADHD) children/adolescents. METHODS: Voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) was performed to examine neuroanatomic distinctions in 18 children/adolescents aged 7.5-13years diagnosed with DSM-IV TR as ADHD (non-medicated). They were compared with 18 healthy matched controls. RESULTS: VBCT findings in ADHDchildren/adolescents revealed reduced cortical thickness in the left superior frontal, left orbito-frontal and left dorsal anterior cingulate cortex. VBM findings confirmed decreased gray matter volume in the left orbito frontal, left middle frontal/dorsolateral prefrontal, left middle temporal and left cerebellum in comparison to control group. A decrease in white matter volume was also observed in the left inferior frontal and left calcarine of ADHDchildren/adolescents. CONCLUSION: Results reflect possible abnormal neuroanatomical development patterns in ADHDchildren.
Authors: Katrina Aberizk; Meghan A Collins; Jean Addington; Carrie E Bearden; Kristin S Cadenhead; Barbara A Cornblatt; Daniel H Mathalon; Thomas H McGlashan; Diana O Perkins; Ming T Tsuang; Scott W Woods; Tyrone D Cannon; Elaine F Walker Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2021-04-28
Authors: Katherine R Luking; Robert J Jirsaraie; Rebecca Tillman; Joan L Luby; Deanna M Barch; Aristeidis Sotiras Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2021-07-14