Virginia Lope1, Miguel Martín2, Adela Castelló1, Soraya Casla3, Amparo Ruiz4, Jose Manuel Baena-Cañada5, Ana Mª Casas6, Lourdes Calvo7, Begoña Bermejo8, Montserrat Muñoz9, Manuel Ramos10, Ana de Juan-Ferré11, Carlos Jara12, Antonio Antón13, Mª Ángeles Jimeno14, Ana Lluch8, Silvia Antolín7, José Ángel García-Sáenz15, Purificación Estévez6, Esperanza Arriola-Arellano5, Joaquín Gavilá4, Beatriz Pérez-Gómez1, Eva Carrasco14, Marina Pollán16. 1. Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Madrid, Spain; Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro (IDIPHIM), Madrid, Spain. 2. Medical Oncology Unit, Hospital Clínico Universitario San Carlos, Madrid, Spain; Health Research Institute Gregorio Marañón, Universidad Complutense, Madrid, Spain. 3. Dpto. Ciencias Sociales de la Actividad Física y del Ocio, Facultad de Ciencias de la Actividad Física y el Deporte, Universidad Politécnica, Madrid, Spain. 4. Medical Oncology Unit, Instituto Valenciano de Oncología, Valencia, Spain. 5. Medical Oncology Unit, Hospital Puerta del Mar, Cádiz, Spain. 6. Medical Oncology Unit, Hospital Virgen del Rocío, Sevilla, Spain. 7. Medical Oncology Unit, Complejo Hospitalario Universitario, A Coruña, Spain. 8. Hematology-Oncology Department, Hospital Clínico Universitario de Valencia/INCLIVA, Universidad de Valencia, Valencia, Spain. 9. Medical Oncology Hospital Clínic and Translational Genomics and Targeted Therapeutics in Solid Tumors, Barcelona, Spain. 10. Medical Oncology Unit, Centro Oncológico de Galicia, A Coruña, Spain. 11. Medical Oncology Unit, Hospital Marqués de Valdecilla, Santander, Spain. 12. Medical Oncology Unit, Hospital Universitario Fundación Alcorcón, Universidad Rey Juan Carlos, Madrid, Spain. 13. Medical Oncology Unit, Instituto de Investigación Sanitaria Aragón, Hospital Universitario Miguel Servet, Zaragoza, Spain. 14. Spanish Breast Cancer Research Group (GEICAM) Headquarters, Madrid, Spain. 15. Medical Oncology Unit, Hospital Clínico Universitario San Carlos, Madrid, Spain. 16. Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Madrid, Spain; Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro (IDIPHIM), Madrid, Spain. Electronic address: mpollan@isciii.es.
Abstract
OBJECTIVE: To examine the influence of physical activity on breast cancer risk and evaluate whether adherence to international recommendations is associated with a decreased risk. METHODS: This is a multicenter matched case-control study where 698 pairs completed a physical activity questionnaire. Recreational physical activity during the last year was quantified in metabolic equivalent hours per week (MET-h/week) and categorized in activities of moderate (3.0-5.9 MET) and vigorous (>6 MET) intensity. The adherence to World Cancer Research Fund and the American Institute for Cancer Research recommendation was also assessed. The association with breast cancer risk, overall and by pathologic subtype, was evaluated using conditional and multinomial logistic regression models. RESULTS: Mean MET-h/week was 16.6 among cases and 20.4 among controls. Premenopausal breast cancer risk decreased by 5% (P=0.007) for every 6 MET-h/week increase in energy expenditure. By contrast, postmenopausal women needed to do more intense exercise to observe benefits. The protection was more pronounced for nulliparous women, as well as for hormone receptor positive and HER2+ tumors. Physically inactive women displayed a 71% increased risk when compared with those who met the international recommendation (P=0.001). Finally, women who were inactive during the previous year, regardless of the overall physical activity reported in previous periods, showed an increased risk when compared to always active women. CONCLUSIONS: Women who report adherence to international physical activity recommendations entail a significant decrease in risk for all pathologic breast cancer subtypes. This is of particular interest in Spain, where a significant increase in overweight and obesity in recent decades is observed. Copyright Â
OBJECTIVE: To examine the influence of physical activity on breast cancer risk and evaluate whether adherence to international recommendations is associated with a decreased risk. METHODS: This is a multicenter matched case-control study where 698 pairs completed a physical activity questionnaire. Recreational physical activity during the last year was quantified in metabolic equivalent hours per week (MET-h/week) and categorized in activities of moderate (3.0-5.9 MET) and vigorous (>6 MET) intensity. The adherence to World Cancer Research Fund and the American Institute for Cancer Research recommendation was also assessed. The association with breast cancer risk, overall and by pathologic subtype, was evaluated using conditional and multinomial logistic regression models. RESULTS: Mean MET-h/week was 16.6 among cases and 20.4 among controls. Premenopausal breast cancer risk decreased by 5% (P=0.007) for every 6 MET-h/week increase in energy expenditure. By contrast, postmenopausal women needed to do more intense exercise to observe benefits. The protection was more pronounced for nulliparous women, as well as for hormone receptor positive and HER2+ tumors. Physically inactive women displayed a 71% increased risk when compared with those who met the international recommendation (P=0.001). Finally, women who were inactive during the previous year, regardless of the overall physical activity reported in previous periods, showed an increased risk when compared to always active women. CONCLUSIONS:Women who report adherence to international physical activity recommendations entail a significant decrease in risk for all pathologic breast cancer subtypes. This is of particular interest in Spain, where a significant increase in overweight and obesity in recent decades is observed. Copyright Â
Authors: Carolina Donat-Vargas; Ángel Guerrero-Zotano; Ana Casas; José Manuel Baena-Cañada; Virginia Lope; Silvia Antolín; José Ángel Garcia-Saénz; Begoña Bermejo; Montserrat Muñoz; Manuel Ramos; Ana de Juan; Carlos Jara Sánchez; Pedro Sánchez-Rovira; Antonio Antón; Joan Brunet; Joaquín Gavilá; Javier Salvador; Esperanza Arriola Arellano; Susana Bezares; Nerea Fernández de Larrea-Baz; Beatriz Pérez-Gómez; Miguel Martín; Marina Pollán Journal: Br J Cancer Date: 2021-09-06 Impact factor: 9.075
Authors: M Pollán; S Casla-Barrio; J Alfaro; C Esteban; M A Segui-Palmer; A Lucia; M Martín Journal: Clin Transl Oncol Date: 2020-02-13 Impact factor: 3.405
Authors: Virginia Lope; Miguel Martín; Adela Castelló; Amparo Ruiz; Ana Mª Casas; José Manuel Baena-Cañada; Silvia Antolín; Manuel Ramos-Vázquez; José Ángel García-Sáenz; Montserrat Muñoz; Ana Lluch; Ana de Juan-Ferré; Carlos Jara; Pedro Sánchez-Rovira; Antonio Antón; José Ignacio Chacón; Angels Arcusa; Mª Angeles Jimeno; Susana Bezares; Jesús Vioque; Eva Carrasco; Beatriz Pérez-Gómez; Marina Pollán Journal: Sci Rep Date: 2019-03-07 Impact factor: 4.379
Authors: Virginia Lope; Ángel Guerrero-Zotano; Ana Casas; José Manuel Baena-Cañada; Begoña Bermejo; Beatriz Pérez-Gómez; Inmaculada Criado-Navarro; Silvia Antolín; Pedro Sánchez-Rovira; Manuel Ramos-Vázquez; Antonio Antón; Adela Castelló; José Ángel García-Saénz; Montserrat Muñoz; Ana de Juan; Raquel Andrés; Antonio Llombart-Cussac; Blanca Hernando; Rosa María Franquesa; Rosalia Caballero; Feliciano Priego-Capote; Miguel Martín; Marina Pollán Journal: Nutrients Date: 2020-10-14 Impact factor: 5.717