Peter D Ahiawodzi1, Richard A Kerber2, Kira C Taylor2, Frank D Groves2, Elizabeth O'Brien2, Joachim H Ix3, Jorge R Kizer4, Luc Djoussé5, Russell P Tracy6, Anne B Newman7, David S Siscovick8, John Robbins9, Kenneth Mukamal10. 1. a Department of Public Health, Campbell University College of Pharmacy and Health Sciences , Campbell University , Buies Creek , NC , United States. 2. b Department of Epidemiology & Population Health, School of Public Health and Information Sciences , University of Louisville , Louisville , KY , United States. 3. c Department of Medicine and Family and Preventive Medicine , University of California San Diego , La Jolla , United States. 4. d Department of Epidemiology and Population Health , Yeshiva University Albert Einstein College of Medicine , Bronx , United States. 5. e Harvard Medical School , Boston , United States. 6. f Departments of Pathology and Biochemistry , University of Vermont College of Medicine , Burlington , United States. 7. g Department of Geriatric Medicine , University of Pittsburgh , Pittsburgh , United States. 8. h Senior Vice President for Research, New York Academy of Medicine , New York , United States. 9. i Deparment of Internal Medicine , University of California Berkeley , Berkeley , United States. 10. j Deparment of General Medicine and Primary Care , Beth Israel Deaconess Medical Center , Boston , United States.
Abstract
CONTEXT: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. OBJECTIVE: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML. MATERIALS AND METHODS: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. RESULTS: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men. DISCUSSION: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. CONCLUSION: Accumulation of CML may be an adverse health consequence of SDB.
CONTEXT: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. OBJECTIVE: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML. MATERIALS AND METHODS: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. RESULTS:Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men. DISCUSSION: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. CONCLUSION: Accumulation of CML may be an adverse health consequence of SDB.
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