Alkis Togias1, Susan F Cooper1, Maria L Acebal2, Amal Assa'ad3, James R Baker4, Lisa A Beck5, Julie Block6, Carol Byrd-Bredbenner7, Edmond S Chan8, Lawrence F Eichenfield9, David M Fleischer10, George J Fuchs11, Glenn T Furuta12,13, Matthew J Greenhawt10, Ruchi S Gupta14, Michele Habich15, Stacie M Jones16, Kari Keaton17, Antonella Muraro18, Marshall Plaut1, Lanny J Rosenwasser19, Daniel Rotrosen1, Hugh A Sampson20, Lynda C Schneider21, Scott H Sicherer22, Robert Sidbury23, Jonathan Spergel24, David R Stukus25, Carina Venter26, Joshua A Boyce27. 1. The National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. 2. The Board of Directors, Food Allergy Research & Education, McLean, Virginia. 3. The Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio. 4. Food Allergy Research & Education, McLean and the Division of Allergy and Clinical Immunology, University of Michigan Health System, Ann Arbor, Michigan. 5. The Department of Dermatology, University of Rochester Medical Center, San Rafael and San Diego, California. 6. The National Eczema Association, San Rafael, California. 7. The Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey. 8. The Division of Allergy and Immunology, Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. 9. The Departments of Dermatology and Pediatrics, San Diego School of Medicine, Rady Children's Hospital, University of California, San Diego, California. 10. The Section of Allergy and Immunology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Denver School of Medicine, Aurora, Columbia. 11. The Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Kentucky Children's Hospital, University of Kentucky College of Medicine, Lexington, Kentucky. 12. The Digestive Health Institute, Children's Hospital Colorado, Aurora, Columbia. 13. The Section of Pediatric Gastroenterology, University of Colorado Denver School of Medicine, Aurora, Columbia. 14. The Division of Academic General Pediatrics and Primary Care, Department of Pediatrics and the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 15. Northwestern Medicine, Central DuPage Hospital, Winfield, Illinois. 16. The Division of Allergy and Immunology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas. 17. Metro DC Food Allergy Support Group, Rockville, Maryland. 18. The Food Allergy Referral Centre, Department of Women and Child Health, Padua University Hospital, Padua, Italy. 19. University of Missouri-Kansas City School of Medicine, Kansas City, Missouri. 20. The Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York. 21. The Division of Pediatric Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, New York. 22. The Division of Allergy and Immunology, Boston Children's Hospital, Boston, Massachusetts. 23. The Department of Pediatrics, Division of Dermatology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington. 24. The Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania. 25. The Department of Pediatrics, Section of Allergy and Immunology, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, Ohio. 26. The Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. 27. The Departments of Medicine and Pediatrics, Harvard Medical School, Boston, Massachusetts.
Abstract
BACKGROUND: Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy. A recent landmark clinical trial and other emerging data suggest that peanut allergy can be prevented through introduction of peanut-containing foods beginning in infancy. OBJECTIVES: Prompted by these findings, along with 25 professional organizations, federal agencies, and patient advocacy groups, the National Institute of Allergy and Infectious Diseases facilitated development of addendum guidelines to specifically address the prevention of peanut allergy. RESULTS: The addendum provides three separate guidelines for infants at various risk levels for the development of peanut allergy and is intended for use by a wide variety of health care providers. Topics addressed include the definition of risk categories, appropriate use of testing (specific IgE measurement, skin prick tests, and oral food challenges), and the timing and approaches for introduction of peanut-containing foods in the health care provider's office or at home. The addendum guidelines provide the background, rationale, and strength of evidence for each recommendation. CONCLUSIONS: Guidelines have been developed for early introduction of peanut-containing foods into the diets of infants at various risk levels for peanut allergy. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.
BACKGROUND:Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institute of Allergy and Infectious Diseases, working with other organizations and advocacy groups, led the development of the first clinical guidelines for the diagnosis and management of food allergy. A recent landmark clinical trial and other emerging data suggest that peanutallergy can be prevented through introduction of peanut-containing foods beginning in infancy. OBJECTIVES: Prompted by these findings, along with 25 professional organizations, federal agencies, and patient advocacy groups, the National Institute of Allergy and Infectious Diseases facilitated development of addendum guidelines to specifically address the prevention of peanutallergy. RESULTS: The addendum provides three separate guidelines for infants at various risk levels for the development of peanutallergy and is intended for use by a wide variety of health care providers. Topics addressed include the definition of risk categories, appropriate use of testing (specific IgE measurement, skin prick tests, and oral food challenges), and the timing and approaches for introduction of peanut-containing foods in the health care provider's office or at home. The addendum guidelines provide the background, rationale, and strength of evidence for each recommendation. CONCLUSIONS: Guidelines have been developed for early introduction of peanut-containing foods into the diets of infants at various risk levels for peanutallergy. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.
Authors: Erin K Willits; Miguel A Park; Martha F Hartz; Cathy D Schleck; Amy L Weaver; Avni Y Joshi Journal: Mayo Clin Proc Date: 2018-10 Impact factor: 7.616
Authors: Ruchi S Gupta; Christopher M Warren; Bridget M Smith; Jialing Jiang; Jesse A Blumenstock; Matthew M Davis; Robert P Schleimer; Kari C Nadeau Journal: JAMA Netw Open Date: 2019-01-04