Hasan Basri Arifoglu1, Bekir Kucuk2, Necati Duru2, Orhan Altunel2, Ahmet Gulhan2, Mustafa Ozen3, Bilal Aygun3, Mustafa Atas2. 1. Department of Ophthalmology, Kayseri Education and Research Hospital, Sanayi Mah. Atatürk Boulevard Hastane Street No: 78, 38010, Kayseri, Turkey. habasa@yahoo.com. 2. Department of Ophthalmology, Kayseri Education and Research Hospital, Sanayi Mah. Atatürk Boulevard Hastane Street No: 78, 38010, Kayseri, Turkey. 3. Department of Haematology, Kayseri Education and Research Hospital, Kayseri, Turkey.
Abstract
PURPOSE: The aim of this study was to investigate the effect of β-thalassemia minor on choroidal, macular, and peripapillary retinal nerve fiber layer thickness. METHODS: To form the sample, we recruited 40 patients with β-thalassemia minor and 44 healthy participants. We used spectral-domain optical coherence tomography to take all measurements of ocular thickness, as well as measured intraocular pressure, axial length, and central corneal thickness. We later analyzed correlations of hemoglobin levels with ocular parameters. RESULTS: A statistically significant difference emerged between patients with β-thalassemia minor and the healthy controls in terms of mean values of subfoveal, nasal, and temporal choroidal thickness (p = 0.001, p = 0.016, and p = 0.010, respectively). Except for central macular thickness, differences in paracentral macular thicknesses between the groups were also significant (superior: p < 0.001, inferior: p = 0.007, temporal: p = 0.001, and nasal: p = 0.005). Also, no statistically significant differences were noted for retinal nerve fiber layer thickness between two groups. CONCLUSION: Mean values of subfoveal, nasal, temporal choroidal, and macular thickness for the four quadrants were significantly lower in patients with β-thalassemia minor than in healthy controls.
PURPOSE: The aim of this study was to investigate the effect of β-thalassemia minor on choroidal, macular, and peripapillary retinal nerve fiber layer thickness. METHODS: To form the sample, we recruited 40 patients with β-thalassemia minor and 44 healthy participants. We used spectral-domain optical coherence tomography to take all measurements of ocular thickness, as well as measured intraocular pressure, axial length, and central corneal thickness. We later analyzed correlations of hemoglobin levels with ocular parameters. RESULTS: A statistically significant difference emerged between patients with β-thalassemia minor and the healthy controls in terms of mean values of subfoveal, nasal, and temporal choroidal thickness (p = 0.001, p = 0.016, and p = 0.010, respectively). Except for central macular thickness, differences in paracentral macular thicknesses between the groups were also significant (superior: p < 0.001, inferior: p = 0.007, temporal: p = 0.001, and nasal: p = 0.005). Also, no statistically significant differences were noted for retinal nerve fiber layer thickness between two groups. CONCLUSION: Mean values of subfoveal, nasal, temporal choroidal, and macular thickness for the four quadrants were significantly lower in patients with β-thalassemia minor than in healthy controls.
Entities:
Keywords:
Choroidal thickness; EDI-OCT; Macular thickness; RNFL thickness; β-thalassemia minor
Authors: Scott A Read; Michael J Collins; Stephen J Vincent; David Alonso-Caneiro Journal: Invest Ophthalmol Vis Sci Date: 2013-11-15 Impact factor: 4.799
Authors: Jie Xu; Liang Xu; Kui Fang Du; Lei Shao; Chang Xi Chen; Jin Qiong Zhou; Ya Xing Wang; Qi Sheng You; Jost B Jonas; Wen Bin Wei Journal: Ophthalmology Date: 2013-05-19 Impact factor: 12.079