Andreas Kronbichler1,2, Johannes Leierer2, Gisela Leierer3, Gert Mayer3, Alina Casian4, Peter Höglund5, Kerstin Westman6, David Jayne1. 1. Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge, UK. 2. Department of Internal Medicine IV (Nephrology and Hypertension). 3. Department of Dermatology and Venereology, Medical University of Innsbruck, Innsbruck, Austria. 4. Guy's Hospital, Louise Coote Lupus Unit, London, UK. 5. Competence Centre for Clinical Research, Skane University Hospital, Lund. 6. Nephrology and Transplantation, Skane University Hospital Malmo, Lund University, Malmo, Sweden.
Abstract
Objective: To assess potential associations for the development of venous thromboembolic events in patients with ANCA-associated vasculitides (AAV). Methods: Four hundred and seventeen patients enrolled to participate in randomized controlled trials conducted by the European Vasculitis Society were identified. Univariate and multivariate analyses were performed to validate previously proposed and identify novel risks associated with venous thromboembolism (VTE) in AAV. Results:VTE occurred in 41 of 417 (9.8%) patients. Uncorrected univariate analysis identified BVAS (odds ratio, OR = 1.05, 95% CI: 1.01, 1.10; P = 0.013), subsequent development of malignancy (OR = 2.6, 95% CI: 1.19, 5.71; P = 0.017), mucous membrane or eye involvement (OR = 2.13, 95% CI: 1.10, 4.11; P = 0.024) and baseline creatinine (OR = 1.08, 95% CI: 0.99, 1.18; P = 0.037) as being associated with the development of VTE. Multivariate analysis highlighted CRP (per 10 mg/l increase, OR = 1.05, 95% CI: 1.01, 1.09; P = 0.025), cutaneous involvement (OR = 4.83, 95% CI: 1.63, 14.38; P = 0.005) and gastrointestinal involvement (OR = 6.27, 95% CI: 1.34, 29.37; P = 0.02) among the BVAS items as well as baseline creatinine (per 100 µmol/l increase, OR = 1.17, 95% CI: 1.02, 1.35; P = 0.029) as being associated with VTEs. Conclusion: Our results highlight a role of CRP, baseline creatinine, and cutaneous and gastrointestinal involvement in the risk stratification as being associated with thromboembolic events. Moreover, there might be an association between VTEs and subsequent development of malignancy and disease activity in general.
RCT Entities:
Objective: To assess potential associations for the development of venous thromboembolic events in patients with ANCA-associated vasculitides (AAV). Methods: Four hundred and seventeen patients enrolled to participate in randomized controlled trials conducted by the European Vasculitis Society were identified. Univariate and multivariate analyses were performed to validate previously proposed and identify novel risks associated with venous thromboembolism (VTE) in AAV. Results:VTE occurred in 41 of 417 (9.8%) patients. Uncorrected univariate analysis identified BVAS (odds ratio, OR = 1.05, 95% CI: 1.01, 1.10; P = 0.013), subsequent development of malignancy (OR = 2.6, 95% CI: 1.19, 5.71; P = 0.017), mucous membrane or eye involvement (OR = 2.13, 95% CI: 1.10, 4.11; P = 0.024) and baseline creatinine (OR = 1.08, 95% CI: 0.99, 1.18; P = 0.037) as being associated with the development of VTE. Multivariate analysis highlighted CRP (per 10 mg/l increase, OR = 1.05, 95% CI: 1.01, 1.09; P = 0.025), cutaneous involvement (OR = 4.83, 95% CI: 1.63, 14.38; P = 0.005) and gastrointestinal involvement (OR = 6.27, 95% CI: 1.34, 29.37; P = 0.02) among the BVAS items as well as baseline creatinine (per 100 µmol/l increase, OR = 1.17, 95% CI: 1.02, 1.35; P = 0.029) as being associated with VTEs. Conclusion: Our results highlight a role of CRP, baseline creatinine, and cutaneous and gastrointestinal involvement in the risk stratification as being associated with thromboembolic events. Moreover, there might be an association between VTEs and subsequent development of malignancy and disease activity in general.
Authors: Alana Nevares; Kinanah Yaseen; Hiromichi Tamaki; James Bena; William Messner; Alexandra Villa-Forte Journal: Rheumatol Adv Pract Date: 2022-07-01
Authors: Fredrik Uhlin; Wladimir Szpirt; Andreas Kronbichler; Annette Bruchfeld; Inga Soveri; Lionel Rostaing; Eric Daugas; Arnaud Lionet; Nassim Kamar; Cédric Rafat; Marek Mysliveček; Vladimír Tesař; Anders Fernström; Christian Kjellman; Charlotte Elfving; Stephen McAdoo; Johan Mölne; Ingeborg Bajema; Elisabeth Sonesson; Mårten Segelmark Journal: J Am Soc Nephrol Date: 2022-03-08 Impact factor: 14.978
Authors: Andreas Kronbichler; Johannes Leierer; Jae Il Shin; Peter A Merkel; Robert Spiera; Philip Seo; Carol A Langford; Gary S Hoffman; Cees G M Kallenberg; E William St Clair; Paul Brunetta; Fernando C Fervenza; Duvuru Geetha; Karina A Keogh; Paul A Monach; Steven R Ytterberg; Gert Mayer; Ulrich Specks; John H Stone Journal: Arthritis Rheumatol Date: 2019-09-25 Impact factor: 10.995
Authors: Carmen E Mendoza; Elizabeth J Brant; Matthew L McDermott; Anne Froment; Yichun Hu; Susan L Hogan; J Charles Jennette; Ronald J Falk; Patrick H Nachman; Vimal K Derebail; Donna O'Dell Bunch Journal: Kidney Int Rep Date: 2019-07-13