Literature DB >> 28052850

Association between Polymorphisms in the Pfmdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal.

Mathieu Gendrot1,2, Silman Diawara3, Marylin Madamet2,4,5, Mame Bou Kounta6, Sébastien Briolant1,2,7,8, Khalifa Ababacar Wade6, Mansour Fall9, Nicolas Benoit2,4,5, Aminata Nakoulima10, Rémy Amalvict2,4,5, Yaya Diémé3, Bécaye Fall3, Boubacar Wade11, Bakary Diatta9,11, Bruno Pradines12,2,3,5.   

Abstract

Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese Plasmodium falciparum isolates to evaluate the association between the number of Asn residues in the polymorphic microsatellite region of the Plasmodium falciparum multidrug resistance 6 gene (Pfmdr6) and the ex vivo susceptibility to antimalarials. A significant association was observed between the presence of 7 or 9 Asn repeats and reduced susceptibility to quinine.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Plasmodium falciparum; antimalarial drug; in vitro; malaria; molecular marker; resistance

Mesh：

Substances：

Year:  2017        PMID： 28052850      PMCID： PMC5328570          DOI： 10.1128/AAC.01183-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  The F423Y mutation in the pfmdr2 gene and mutations N51I, C59R, and S108N in the pfdhfr gene are independently associated with pyrimethamine resistance in Plasmodium falciparum isolates.

Authors:  Sébastien Briolant; Hervé Bogreau; Marine Gil; Housem Bouchiba; Eric Baret; Rémy Amalvict; Christophe Rogier; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2012-02-06       Impact factor: 5.191

2.  Differential association of Plasmodium falciparum Na+/H+ exchanger polymorphism and quinine responses in field- and culture-adapted isolates of Plasmodium falciparum.

Authors:  Stéphane Pelleau; Lionel Bertaux; Sébastien Briolant; Michael T Ferdig; Véronique Sinou; Bruno Pradines; Daniel Parzy; Ronan Jambou
Journal:  Antimicrob Agents Chemother       Date:  2011-09-26       Impact factor: 5.191

3.  Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.

Authors:  Ric N Price; Anne-Catrin Uhlemann; Alan Brockman; Rose McGready; Elizabeth Ashley; Lucy Phaipun; Rina Patel; Kenneth Laing; Sornchai Looareesuwan; Nicholas J White; François Nosten; Sanjeev Krishna
Journal:  Lancet       Date:  2004 Jul 31-Aug 6       Impact factor: 79.321

4.  Artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
Journal:  N Engl J Med       Date:  2009-07-30       Impact factor: 91.245

5.  Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.

Authors:  John Okombo; Abdirahman I Abdi; Steven M Kiara; Leah Mwai; Lewa Pole; Colin J Sutherland; Alexis Nzila; Lynette Isabella Ochola-Oyier
Journal:  Antimicrob Agents Chemother       Date:  2013-09-30       Impact factor: 5.191

6.  Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin.

Authors:  Nathalie Wurtz; Bécaye Fall; Aurélie Pascual; Mansour Fall; Eric Baret; Cheikhou Camara; Aminata Nakoulima; Bakary Diatta; Khadidiatou Ba Fall; Pape Saliou Mbaye; Yaya Diémé; Raymond Bercion; Boubacar Wade; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2014-09-08       Impact factor: 5.191

7.  Spread of artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Elizabeth A Ashley; Mehul Dhorda; Rick M Fairhurst; Chanaki Amaratunga; Parath Lim; Seila Suon; Sokunthea Sreng; Jennifer M Anderson; Sivanna Mao; Baramey Sam; Chantha Sopha; Char Meng Chuor; Chea Nguon; Siv Sovannaroth; Sasithon Pukrittayakamee; Podjanee Jittamala; Kesinee Chotivanich; Kitipumi Chutasmit; Chaiyaporn Suchatsoonthorn; Ratchadaporn Runcharoen; Tran Tinh Hien; Nguyen Thanh Thuy-Nhien; Ngo Viet Thanh; Nguyen Hoan Phu; Ye Htut; Kay-Thwe Han; Kyin Hla Aye; Olugbenga A Mokuolu; Rasaq R Olaosebikan; Olaleke O Folaranmi; Mayfong Mayxay; Maniphone Khanthavong; Bouasy Hongvanthong; Paul N Newton; Marie A Onyamboko; Caterina I Fanello; Antoinette K Tshefu; Neelima Mishra; Neena Valecha; Aung Pyae Phyo; Francois Nosten; Poravuth Yi; Rupam Tripura; Steffen Borrmann; Mahfudh Bashraheil; Judy Peshu; M Abul Faiz; Aniruddha Ghose; M Amir Hossain; Rasheda Samad; M Ridwanur Rahman; M Mahtabuddin Hasan; Akhterul Islam; Olivo Miotto; Roberto Amato; Bronwyn MacInnis; Jim Stalker; Dominic P Kwiatkowski; Zbynek Bozdech; Atthanee Jeeyapant; Phaik Yeong Cheah; Tharisara Sakulthaew; Jeremy Chalk; Benjamas Intharabut; Kamolrat Silamut; Sue J Lee; Benchawan Vihokhern; Chanon Kunasol; Mallika Imwong; Joel Tarning; Walter J Taylor; Shunmay Yeung; Charles J Woodrow; Jennifer A Flegg; Debashish Das; Jeffery Smith; Meera Venkatesan; Christopher V Plowe; Kasia Stepniewska; Philippe J Guerin; Arjen M Dondorp; Nicholas P Day; Nicholas J White
Journal:  N Engl J Med       Date:  2014-07-31       Impact factor: 91.245

8.  In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo.

Authors:  Sébastien Briolant; Stéphane Pelleau; Hervé Bogreau; Philippe Hovette; Agnès Zettor; Jacky Castello; Eric Baret; Rémy Amalvict; Christophe Rogier; Bruno Pradines
Journal:  Malar J       Date:  2011-02-11       Impact factor: 2.979

9.  Multinormal in vitro distribution of Plasmodium falciparum susceptibility to piperaquine and pyronaridine.

Authors:  Aurélie Pascual; Marilyn Madamet; Sébastien Briolant; Tiphaine Gaillard; Rémy Amalvict; Nicolas Benoit; Dominique Travers; Bruno Pradines
Journal:  Malar J       Date:  2015-02-05       Impact factor: 2.979

10.  In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger transporter (Pfnhe-1) gene in 393 isolates from Dakar, Senegal.

Authors:  Aurélie Pascual; Bécaye Fall; Nathalie Wurtz; Mansour Fall; Cheikhou Camara; Aminata Nakoulima; Eric Baret; Bakary Diatta; Khadidiatou Ba Fall; Pape Saliou Mbaye; Yaya Diémé; Raymond Bercion; Hervé Bogreau; Sébastien Briolant; Christophe Rogier; Boubacar Wade; Bruno Pradines
Journal:  Malar J       Date:  2013-06-07       Impact factor: 2.979
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  4 in total

1.  Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa.

Authors:  Marie Gladys Robert; Francis Foguim Tsombeng; Mathieu Gendrot; Joel Mosnier; Rémy Amalvict; Nicolas Benoit; Marylin Torrentino-Madamet; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2018-10-24       Impact factor: 5.191

2.  Malaria, tuberculosis and HIV: what's new? Contribution of the Institut Hospitalo-Universitaire Méditerranée Infection in updated data.

Authors:  Lionel Almeras; Leonardo K Basco; Cheikh Sokhna; Stéphane Ranque; Philippe Parola; Christian Devaux; Philippe Brouqui; Michel Drancourt; Bruno Pradines
Journal:  New Microbes New Infect       Date:  2018-07-04

3.  Contribution of the French army health service in support of expertise and research in infectiology in Africa.

Authors:  B Pradines; C Rogier
Journal:  New Microbes New Infect       Date:  2018-06-04

4.  Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?

Authors:  Francis Foguim Tsombeng; Mathieu Gendrot; Marie Gladys Robert; Marylin Madamet; Bruno Pradines
Journal:  Malar J       Date:  2019-08-23       Impact factor: 2.979
  4 in total

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