Literature DB >> 28051364

The Role of Myeloid-Derived Suppressor Cells in Viral Infection.

Megan A O'Connor1, Jessica L Rastad1, William R Green1,2.   

Abstract

Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells that are well described as potent immune regulatory cells during human cancer and murine tumor models. Reports of MDSCs during viral infections remain limited, and their association with immunomodulation of viral diseases is still being defined. Here, we provide an overview of MDSCs or MDSC-like cells identified during viral infections, including murine viral models and human viral diseases. Understanding the similarities and/or differences of virally induced versus tumor-derived MDSCs will be important for designing future immunotherapeutic approaches.

Entities:  

Keywords:  MDSCs; immunotherapeutic approaches; viral infections

Mesh：

Year:  2017        PMID： 28051364      PMCID： PMC5346953          DOI： 10.1089/vim.2016.0125

Source DB:  PubMed          Journal:  Viral Immunol        ISSN： 0882-8245            Impact factor:   2.257


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