| Literature DB >> 28051316 |
Sianne Schwikkard1,2, Alaa Alqahtani1, Walter Knirsch3, Wolfgang Wetschnig3, Andrius Jaksevicius2, Elizabeth I Opara2, Moses K Langat1,4, Jackie L Andriantiana5, Dulcie A Mulholland1,4.
Abstract
The genus Rhodocodon (Hyacinthaceae sensu APG II) is endemic to Madagascar, and its phytochemistry has not been described previously. The phytochemistry of three species in this genus has been investigated, and eight compounds, including three bufadienolides (compounds 1, 4, and 5), a norlignan (2), and four homoisoflavonoids (compounds 3 and 6-8), have been isolated and identified. Compounds 1-3 and 6-8 have not been described previously. The COX-2 inhibitory activity of compound 6 and compound 7 acetate (compound 7A) was investigated on isolated colorectal cancer cells. Compounds 6 and 7A inhibited COX-2 by 10% and 8%, respectively, at a concentration of 12.5 μM compared to 12% for 1 mM aspirin (the positive control).Entities:
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Year: 2017 PMID： 28051316 DOI： 10.1021/acs.jnatprod.6b00240
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050