Literature DB >> 28050380

Coincidental Finding of Beta Thalassaemia Minor in a Patient of Lacquer Thinner Poisoning Presenting as Methaemoglobinemia.

Charu Agarwal1, Anisha Mohanpuria2, Gurdeep Buxi3, Vijay Kumar4.   

Abstract

Lacquer thinner, commonly used for removing household paints, is known to contain various aromatic hydrocarbons and naphtha; if ingested, may cause methaemoglobinemia. We report a case of 13-year-old girl who presented with episodes of vomiting, abdominal pain and numbness of limbs. Peripheral blood smear showed few fragmented erythrocytes and 10-12 nucleated red blood cells /100 white blood cells. Reticulocyte count was 15% with presence of Heinz bodies. There was a history of accidental ingestion of lacquer paint thinner. Levels of methaemoglobin were very high along with raised HbA2 levels. An impression of haemolytic anaemia, due to lacquer thinner paint poisoning, with methaemoglobinemia was given. Incidentally High Performance Liquid Chromatography (HPLC) revealed increased HbA2 levels i.e., heterozygous inheritance of beta thalassaemia minor. Patient responded well to methylene blue. Blood transfusion was performed and symptomatic treatment was given.

Entities:  

Keywords:  Haemolytic Anaemia; Heinz bodies; Heterozygous inheritance

Year:  2016        PMID: 28050380      PMCID: PMC5198333          DOI: 10.7860/JCDR/2016/20625.8847

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  4 in total

Review 1.  Methemoglobinemia: etiology, pharmacology, and clinical management.

Authors:  R O Wright; W J Lewander; A D Woolf
Journal:  Ann Emerg Med       Date:  1999-11       Impact factor: 5.721

2.  Acute methaemoglobinaemia due to ingestion of nitrobenzene (paint solvent).

Authors:  Hema Saxena; Anand Prakash Saxena
Journal:  Indian J Anaesth       Date:  2010-03

3.  Thinner intoxication manifesting as methemoglobinemia.

Authors:  Sanjay Verma; Sunil Gomber
Journal:  Indian J Pediatr       Date:  2009-04-06       Impact factor: 1.967

4.  Methemoglobinemia as a result of accidental lacquer thinner poisoning.

Authors:  Ranju Singh; Stalin Vinayagam; Homay Vajifdar
Journal:  Indian J Crit Care Med       Date:  2012-01
  4 in total

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