Vasavi Rakesh Gorantla1, Sudhakar Pemminati2, Vernon Bond3, Dewey G Meyers4, Richard Mark Millis5. 1. Assistant Professor, Department of Behavioural Sciences and Neuroscience, AUA College of Medicine and Manipal University, Antigua and Department of Anatomy, Melaka Manipal Medical College, Manipal University , Manipal, India . 2. Associate Professor, Department of Medical Pharmacology, AUA College of Medicine , Antigua . 3. Professor, Department of Recreation, Human Performance & Leisure Studies and Exercise Science & Human Nutrition Laboratory, Howard University Cancer Centre , Washington, DC 20060, United States of America . 4. Professor, Department of Behavioural Science and Neuroscience, AUA College of Medicine , Antigua . 5. Professor, Department of Medical Physiology, AUA College of Medicine , Antigua .
Abstract
INTRODUCTION: An aerobic exercise (Ex) augments neurogenesis and may ameliorate learning and memory deficits in the rat Kainic Acid (KA) model of temporal lobe epilepsy in the short-term but whether it reverses learning and memory deficits after a substantial period of delay remains unclear. AIM: This study tests the hypothesis that aerobic Ex attenuates the learning and memory deficits associated with kainate seizures in the long-term. MATERIALS AND METHODS: A total of 60 rats were subjected to chemical lesioning using KA and to an Ex intervention consisting of a 30 days period of daily swimming for 15 min, immediately after KA lesioning (immediate exposure) or after a 60 days period of normal activity (delayed exposure). We evaluated spatial learning on a T-maze test, expressed as percentage of correct responses. We evaluated memory on a passive-avoidance test, expressed as time spent in a compartment in which the rats were previously exposed to an aversive stimulus. RESULTS: Ex increases the percentage of correct responses, percentage bias, and number of alternations, associated with the T-maze testing for the normal control, sham-operated control and kainate-lesioned animals after both immediate and delayed exposures to Ex. Ex decreased the time exposed to the aversive stimulus in the smaller compartment of the two-compartment passive-avoidance test, also for the normal control, sham-operated control and kainate-lesioned animals after both immediate and delayed exposures to Ex. CONCLUSION: These findings suggest that, after temporal lobe epileptic seizures in rats, swimming exercise may attenuate the learning and memory deficits, even if the exercise treatment is delayed.
INTRODUCTION: An aerobic exercise (Ex) augments neurogenesis and may ameliorate learning and memory deficits in the ratKainic Acid (KA) model of temporal lobe epilepsy in the short-term but whether it reverses learning and memory deficits after a substantial period of delay remains unclear. AIM: This study tests the hypothesis that aerobic Ex attenuates the learning and memory deficits associated with kainate seizures in the long-term. MATERIALS AND METHODS: A total of 60 rats were subjected to chemical lesioning using KA and to an Ex intervention consisting of a 30 days period of daily swimming for 15 min, immediately after KA lesioning (immediate exposure) or after a 60 days period of normal activity (delayed exposure). We evaluated spatial learning on a T-maze test, expressed as percentage of correct responses. We evaluated memory on a passive-avoidance test, expressed as time spent in a compartment in which the rats were previously exposed to an aversive stimulus. RESULTS: Ex increases the percentage of correct responses, percentage bias, and number of alternations, associated with the T-maze testing for the normal control, sham-operated control and kainate-lesioned animals after both immediate and delayed exposures to Ex. Ex decreased the time exposed to the aversive stimulus in the smaller compartment of the two-compartment passive-avoidance test, also for the normal control, sham-operated control and kainate-lesioned animals after both immediate and delayed exposures to Ex. CONCLUSION: These findings suggest that, after temporal lobe epilepticseizures in rats, swimming exercise may attenuate the learning and memory deficits, even if the exercise treatment is delayed.
Authors: Margaret P Jacobs; Gabrielle G Leblanc; Amy Brooks-Kayal; Frances E Jensen; Dan H Lowenstein; Jeffrey L Noebels; Dennis D Spencer; John W Swann Journal: Epilepsy Behav Date: 2009-03 Impact factor: 2.937
Authors: Gisela H Maia; José L Quesado; Joana I Soares; Joana M do Carmo; Pedro A Andrade; José P Andrade; Nikolai V Lukoyanov Journal: PLoS One Date: 2014-01-07 Impact factor: 3.240
Authors: G Curia; C Lucchi; J Vinet; F Gualtieri; C Marinelli; A Torsello; L Costantino; G Biagini Journal: Curr Med Chem Date: 2014 Impact factor: 4.530