Efficacy of Carbon Microcoils in Relieving Cervicogenic Dizziness.

Introduction Cervical pain contributes to postural deviations and imbalance. Nanotechnology may be used for the treatment of neck pain by fixing to the skin small rounds silicone patches containing double spiral carbon nanotubes arranged in the form of a coil (Helical), which would then relieve dizziness caused by muscular contraction. Objective The objective of this study is to Evaluate pain and dizziness scores before and after Helical patches effect on cervicogenic dizziness treatment. Methods The selected patients should have neck pain arising from muscle contraction with loss of balance or instability lasting more than 90 days and normal electrooculography. Treatment consisted of placing 10 Helical patches distributed as follows: two in the upper cervical area, two in the lower cervical area (near the 5th and 6th vertebrae), two in the upper trapezius muscle area (between neck and shoulder), and four in the tender point area (as reported by the patient). Using a Visual Analogue Scale (VAS), we matched pain and dizziness scores from Day 1 to those from Day 15 and Day 30 using Mann-Whitney test. Results There was a significant difference between pain score reported on Day 1 and Day 15 (Z = 2.43, U = 5, p = 0.01). We also found significant differences between dizziness scores reported on days 1 and 15 (Z = 2.62, U = 3.5, p = 0.01) and days 1 and 30 (Z = 2.36, U = 5.5, p = 0.01). Conclusion The Helical patches seem to be an effective treatment for cervicogenic dizziness.

Introduction

Dizziness is a common condition that occurs in people of all ages.1 A recent domiciliary survey in the city of São Paulo reported an incredible dizziness prevalence of 42% in the population.2 The medical diagnosis of dizziness is often challenging because of its varied etiologies and manifestations, one of which is cervicogenic dizziness.

Cervicogenic dizziness arises from the abnormal afferent inputs from the proprioceptors of the extensor muscles and joints of the neck, as well as from localized, immediate, and sustained pain.3 These conflicting signals diverge from visual and vestibular network in the central nervous system (CNS).4 5 This type of unmatched balance integration in the CNS is experienced as dizziness. In our clinical experience, the most common complaints during episodes of dizziness related to cervical pain are disorientation and mild instability, which can last from minutes to hours and increase with cervical movement and/or worsening of neck pain. We also observe a temporal relationship between dizziness and neck pain, as well as an association between the relief of cervical pain and relief from dizziness. Some patients with cervical pain may also report visual conflict and falls.6 7 Neck pathology as trauma, arthritis, whiplash, articular block, trigger points, tender points, and disc herniation are the common etiological diagnoses.

The prevalence of chronic pain in the city of São Paulo is 28.7% and 22.1% of these cases are associated with “spinal problems”.8 According to Giamberardino et al, musculoskeletal pain affects 85% of the population at some point in their lives. Myofascial pain is the most common form of musculoskeletal pain.9 Cervical pain is a type of myofascial pain and is treated using several different well-documented techniques. Among the non-pharmacologic techniques, there are those that use heat as a therapeutic strategy, such as the use of thermal bags, ultra-sound, paraffin baths, infrared light, bier ovens, or whirlpool hydrotherapy and hydromassage bathtubs. The use of nanotechnology stands out among newer thermotherapy-based techniques developed for the treatment of neck pain.10 Nanotechnology could be used for the treatment of neck pain by fixing to the skin small rounds silicone patches containing double spiral carbon nanotubes arranged in the form of a coil (Helical, Miyasaka Rubber Co., Chino, Nagano, Japan). These patches are designed for home use, made of an inert material, do not contain any type of drugs, and can be purchased without a medical prescription. When placed over the skin, the patches absorb the electromagnetic waves from the tense muscles, find resistance as they flow through the carbon nanotubes, induce heat, and lead to muscle relaxation.11 We thus expect that this treatment could ease neck pain, therefore relieving dizziness from muscular contraction. Our aims were to evaluate pain and dizziness scores before and after Helical patches, as well as their effect on cervicogenic dizziness treatment.

Method

Here we present a series of case studies approved by the ethics committee of our institution under the number 1.433.854 from March 2nd, 2016. We selected eight patients diagnosed with cervicogenic dizziness from the Neurotology Outpatient Day Clinic of Hospital das Clínicas, Universidade de São Paulo.

The patients underwent a physical evaluation of the cervical region. The same therapist performed all examinations. For the initial evaluation, patients were placed in supine position on a stretcher, with the therapist sitting behind their head. The therapist performed neck and shoulder manual palpation to identify tender areas, as well as muscle contractions. The mobility of the cervical spine was tested in the pitch axis using the Maitland technique.12

Our inclusion criteria were: 1) dizziness with loss of balance or instability lasting more than 90 days, 2) neck pain arising from muscle contraction and 3) normal electrooculography. Our exclusion criteria were 1) psychiatric disease, 2) neurological disease, 3) orthopedic disease, 4) cognitive deficits 5) neck pain from articular etiology and 6) the use of drugs for the treatment of pain or dizziness. The selected patients received guidance on all procedures throughout the study length and provided informed consent.

Patients reported their pain and dizziness levels before, during, and after the treatment using a Visual Analogue Scale (VAS), where the absence of symptoms corresponded to a zero score and the maximum bearable intensity was scored as 10 (Fig. 1).

Fig. 1

“Visual Analogue Scale – VAS” presented to the patient.

The treatment consisted of placing 10 Helical patches spread as follows (Fig. 2):

Fig. 2

Distribution of the 10 tablets containing nanotubes.

Two in the upper cervical area (suboccipital);

Two in the lower cervical area (near the 5th and 6th vertebrae);

Two in the upper trapezius muscle area (between neck and shoulder);

Four in the tender point area (as reported by the patient).

In a preliminary study conducted before this one, we noticed a decrease in pain and dizziness scores throughout two weeks of patches treatment. Therefore, we tracked out the patient on a biweekly basis. We changed the patches during the first visit, which was 15 days after the beginning of treatment. At this point, one of the subjects was excluded from the study due to patch loss. We recorded the remaining seven subjects pain and dizziness levelś using the VAS on a twice week basis. A Computerized Dynamic Posturography (CPD) was performed at the end of four weeks. We plotted sex, age, pain, and dizziness scores in a table. We analyzed data by mean and standard deviation or using Mann-Whitney test depending on variable category. We also generated a box plot with median, maximum, and minimum values, (p < 0.05).

Result

Our sample consisted of five women and two men, with ages varied between 50 and 74 years (mean and standard deviation = 60.71 ± 8.19). VAS ratio scores recorded on day 1 and 15 and day 1 and 30 are summarized in Table 1.

Table 1

Individual pain and dizziness scores on the first, fifteenth, and thirtieth days of the experiment

Patients	Sex	Age	Day 1		Day 15		Day 30
			Pain	Dizziness	Pain	Dizziness	Pain	Dizziness
NFS	F	67	10	6	5	2	8	3
CBR	M	59	8	7	4	3	3	2
RRRC	F	54	8	8	4	4	5	0
JALL	F	50	5	8.5	6	0	9	8
CMPA	F	64	8	9	3	0	4	0
LN	F	74	8	8	7	8	4	6
JMC	M	57	5	5	3	5	3	3
Mann-Whitney Test			Z		2.43*	2.62*	1.66	2.36*
			U		5*	3.5*	11	5.5*

The Z and U indexes for p ≤ 0.05 of a two-tailed curve are also calculated. Asterisk (*) indicates statistical significance.

Note: Results of the Mann-Whitney test comparing data from day 1 to day 15 and from day 1 to day 30 are presented.

We matched pain and dizziness scores from the day 1 to those from day 15 and day 30 using Mann-Whitney test for small samples. There was a significant difference between pain score reported on day 1 and 15 (Z = 2.43, U = 5, p = 0.01). However, no such difference was found when comparing the day 1 and 30 (Z = 1.66, U = 11, p = 0.09) (Table 1). The results are present as a box plot (Fig. 3).

Fig. 3

Box plot of the VAS pain scores reported during the study period.

We also found significant differences between dizziness scores reported at days 1 and 15 (Z = 2.62, U = 3.5, p = 0.01) and days 1 and 30 (Z = 2.36, U = 5.5, p = 0.01) [Table 1]. The results appear as a box plot (Fig. 4).

Fig. 4

Box plot of the VAS dizziness score reported during the study period.

We observed no side effects, such as itching or hyperemia, in our patients. However, one of the patients lost a patch and was excluded from the sample. None of the patients used pain relief medication during the time treatment.

Discussion

Every year, 11 to 14% of the economically active population report functional limitations and missing work due to neck pain.13 Risk factors include repetitive work, bad postural habits, stress, smoking, and previous trauma. The resulting cervical injury contributes to postural deviations and to anterior-posterior imbalance in the affected subjects.13

The relationship between the cervical spine and vestibular pathways is well-documented in the literature.6 14 15 Many therapies are reportedly beneficial for neck pain relief and, thus, for dizziness amelioration. However, none of the previous reported therapies combines low cost, low side effects, and sustains improvement.6 14 15 We decided to analyze the efficacy of carbon nanotube patches (Helical) for the treatment of cervicogenic dizziness given that it does not contain drugs, is feasible to use, and known to be effective on neck pain relief.10

The double-helical carbon nanotubes within the patches are structures capable of absorbing electromagnetic waves. When in contact with the skin of the affected muscle, the heat elicited from the nanotubes is able to restore local blood flow and tissue homeostasis, as well as oxygenate, and reestablish normal muscle activity. We attached the patches over tender skin areas as well as acupuncture points, using an adhesive tape.11 16 According to the manufacturer, the patient may experience local mild itching and eczema, side effects that we did not observe in our study.

The average age of our sample is comparable to that previously reported for patients with cervicogenic dizziness, who are usually in the fifth to sixth decade of life. The pain and dizziness scores are usually described as moderate to severe. Our sample reached a 7.5 mean VAS score, corroborating our previously clinical judgement. Prior clinical trial study reported a significant decrease in pain VAS scores three weeks after the patches treatment.10 In the current study, we measured pain scores at two time points: 2 and 4 weeks after the beginning of the treatment. We notice that relief of the symptoms occurred in six subjects (86%), on treatment day 15 (p ≤ 0.01). After 30 days, three subjects reported an increase in pain scores compared with day 15. However, they still had lower pain scores compared with those on day 1 (p ≤ 0.09). Our results suggest that the patches have their best analgesic peak around 15 days after treatment onset, at which time they should be change (Fig. 3).

Our main goal was to evaluate effectiveness of the patches on cervicogenic dizziness. We noticed a significant relief on dizziness symptoms both after day 15 (p = 0.01) and day 30 (p = 0.01). Three subjects (42%) reported dizziness scores improvement after day 15 and sustained it until day 30. Two subjects (28%) reported dizziness relief only by day 30. Two patients (28%) noticed worsening on dizziness scores between the day 15 and 30, after symptoms relief in the first two weeks. It seems that patch effects on dizziness scores remained even after the analgesic peak (Fig. 4).

Conclusion

The Helical patches seem to be an effective treatment for cervicogenic dizziness. The most hopeful aspects of carbon nanotubes are that they do not contain any drugs and that they act by mild heat rise. We believe that the main asset of this therapy is that it provides sustained heat flow, which results in tension muscles relaxation. The absence of side effects in our sample suggests good use tolerance. Our sample consisted of a small group of patients and new studies are necessary to verify the efficacy of this new technique.