BACKGROUND: Aeroallergen sensitization is related to the coexistence of allergic diseases, but the nature of this relationship is poorly understood. The aim of this study was to clarify the relationship of polysensitization with allergic multimorbidities and the severity of allergic diseases. METHODS: This study is a cross-sectional analysis of 3,368 Korean children aged 6-7 years-old. We defined IgE-mediated allergic diseases based on structured questionnaires, and classified the sensitivity to 18 aeroallergens by logistic regression and the Ward hierarchical clustering method. The relationship of polysensitization (positive IgE responses against 2 or more aeroallergens classes) with allergic multimorbidities (coexistence of 2 or more of the following allergic diseases: asthma, rhinitis, eczema, and conjunctivitis) and severity of allergic diseases was determined by ordinal logistic regression analysis. RESULTS: The rate of polysensitization was 13.6% (n = 458, 95% CI 12.4-14.8) and that of allergic multimorbidity was 23.5% (n = 790, 95% CI 22.0-24.9). Children sensitized to more aeroallergens tended to have more allergic diseases (rho = 0.248, p < 0.001), although the agreement between polysensitization and multimorbidity was poor (kappa = 0.11, p < 0.001). The number allergen classes to which a child was sensitized increased the risk of wheezing attacks (1 allergen: adjusted odds ratio [aOR] 2.22, 4 or more allergens: aOR 9.39), absence from school (1 allergen: aOR 1.96, 3 allergens: aOR 2.08), and severity of nasal symptoms (1 allergen: aOR 1.61, 4 or more allergens: aOR 4.38). CONCLUSION: Polysensitization was weakly related to multimorbidity. However, the number of allergens to which a child is sensitized is related to the severity of IgE-mediated symptoms.
BACKGROUND: Aeroallergen sensitization is related to the coexistence of allergic diseases, but the nature of this relationship is poorly understood. The aim of this study was to clarify the relationship of polysensitization with allergic multimorbidities and the severity of allergic diseases. METHODS: This study is a cross-sectional analysis of 3,368 Korean children aged 6-7 years-old. We defined IgE-mediated allergic diseases based on structured questionnaires, and classified the sensitivity to 18 aeroallergens by logistic regression and the Ward hierarchical clustering method. The relationship of polysensitization (positive IgE responses against 2 or more aeroallergens classes) with allergic multimorbidities (coexistence of 2 or more of the following allergic diseases: asthma, rhinitis, eczema, and conjunctivitis) and severity of allergic diseases was determined by ordinal logistic regression analysis. RESULTS: The rate of polysensitization was 13.6% (n = 458, 95% CI 12.4-14.8) and that of allergic multimorbidity was 23.5% (n = 790, 95% CI 22.0-24.9). Children sensitized to more aeroallergens tended to have more allergic diseases (rho = 0.248, p < 0.001), although the agreement between polysensitization and multimorbidity was poor (kappa = 0.11, p < 0.001). The number allergen classes to which a child was sensitized increased the risk of wheezing attacks (1 allergen: adjusted odds ratio [aOR] 2.22, 4 or more allergens: aOR 9.39), absence from school (1 allergen: aOR 1.96, 3 allergens: aOR 2.08), and severity of nasal symptoms (1 allergen: aOR 1.61, 4 or more allergens: aOR 4.38). CONCLUSION: Polysensitization was weakly related to multimorbidity. However, the number of allergens to which a child is sensitized is related to the severity of IgE-mediated symptoms.
Authors: Shadan Ghandizadeh Dezfouli; Nadine Mothes-Luksch; Annika N Jensen; Eva Untersmayr; Michael Kundi; Erika Jensen-Jarolim Journal: World Allergy Organ J Date: 2020-11-21 Impact factor: 4.084
Authors: Jean Bousqet; Filip Raciborski; Jean Bousquet; Andrzej Namysłowski; Edyta Krzych-Fałta; Aneta Tomaszewska; Barbara Piekarska; Piotr Samel-Kowalik; Artur Z Białoszewski; Artur Walkiewicz; Agnieszka Lipiec; Oksana Wojas; Krzysztof Samoliński; Anna Szylling; Wojciech Zieliński; Adam Sybilski; Aleksandra Grąbczewska; Bolesław Samoliński Journal: Clin Transl Allergy Date: 2019-02-11 Impact factor: 5.871
Authors: Myongsoon Sung; Dong Keon Yon; Seung Won Lee; Ju Hee Kim; Hey Sung Baek; Hye Mi Jee; Youn Ho Shin; Man Yong Han Journal: Biomed Res Int Date: 2021-11-18 Impact factor: 3.411
Authors: Oliver Brandt; Benjamin Wegenstein; Ivan Müller; Danielle Smith; Siphesihle Nqweniso; Larissa Adams; Simon Müller; Rosa du Randt; Uwe Pühse; Markus Gerber; Alexander A Navarini; Jürg Utzinger; Niklaus D Labhardt; Christian Schindler; Cheryl Walter Journal: Clin Exp Allergy Date: 2022-03-02 Impact factor: 5.401