| Literature DB >> 28043921 |
Cui Chang1, Te Liu2, Yongyi Huang3, Wenxing Qin4, Hongtu Yang5, Juan Chen6.
Abstract
The cluster of microRNAs (miRNAs) in the DLK1-DIO3 genomic imprinted region contains several miRNAs that have a significant regulatory role in tumor proliferation and invasion. One of these miRNAs is miR-134-3p, and its expression changes significantly in human ovarian cancer stem cells (OCSCs) and in CD44-/CD133- ovarian cancer. The results of a luciferase assay showed that miR-134-3p silenced RAB27A by binding to the 3'-UTR of RAB27A mRNA. Overexpression of miR-134-3p in human OCSCs can not only inhibit the expression of RAB27A but also can effectively downregulate the expression of some tumor proliferation and invasion genes. Overexpression of miR-134-3p can not only inhibit the in vitro proliferation and cell cycle progression of human OCSCs but also can decrease the tumorigenicity in nude mice.Entities:
Keywords: DLK1-DIO3 microRNA cluster; MicroRNA-134-3p (miR-134-3p); Ovarian cancer stem cells (OCSCs); RAB27A
Mesh：
Substances：
Year: 2016 PMID： 28043921 DOI： 10.1016/j.gene.2016.12.030
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688