Shaheen Durrani-Kolarik1, Kandamurugu Manickam2, Bernadette Chen3. 1. Nationwide Children's Hospital, Columbus, Ohio. 2. Nationwide Children's Hospital, Columbus, Ohio; Division of Human Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Pediatrics, Ohio State University, Columbus, Ohio. 3. Nationwide Children's Hospital, Columbus, Ohio; Department of Pediatrics, Ohio State University, Columbus, Ohio; Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio. Electronic address: bernadette.chen@nationwidechildrens.org.
Abstract
BACKGROUND: COL4A1 on chromosome 13q34 encodes the alpha 1 chain of type IV collagen, a component of basal membranes. It is expressed mainly in the brain, muscles, kidneys, and eyes. COL4A1 mutations can remain asymptomatic or cause devastating disease. Neonates and children may present with porencephaly, intracerebral hemorrhage, or hemiparesis, whereas adults tend to develop intracranial aneurysms or retinal arteriolar tortuosities. PATIENT DESCRIPTION: We describe a term infant with encephalomalacia, extensive intrauterine stroke and anterior segment dysgenesis with a de novo mutation in COL4A1. CONCLUSIONS: Identification of this mutation in affected individuals has implications for perinatal management and genetic counseling.
BACKGROUND:COL4A1 on chromosome 13q34 encodes the alpha 1 chain of type IV collagen, a component of basal membranes. It is expressed mainly in the brain, muscles, kidneys, and eyes. COL4A1 mutations can remain asymptomatic or cause devastating disease. Neonates and children may present with porencephaly, intracerebral hemorrhage, or hemiparesis, whereas adults tend to develop intracranial aneurysms or retinal arteriolar tortuosities. PATIENT DESCRIPTION: We describe a term infant with encephalomalacia, extensive intrauterine stroke and anterior segment dysgenesis with a de novo mutation in COL4A1. CONCLUSIONS: Identification of this mutation in affected individuals has implications for perinatal management and genetic counseling.
Authors: Aaron P Adam; Kurlen S E Payton; Pedro A Sanchez-Lara; Margaret P Adam; Ghayda M Mirzaa Journal: Am J Med Genet A Date: 2021-05-03 Impact factor: 2.802
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