[Development of motor and emotional disorders in rats during daily administration of subliminal doses of picrotoxin].

It was shown in the experiments on rats, that three neuropathological syndromes develop as a result of daily subthreshold picrotoxin injections (1.25 mg/kg). Maximal expression of syndromes was different during various periods of kindling. The development of seizure syndrome was followed by prevalence of enhanced electrical activity in hippocampus; the development of "akinetic" syndrome was the same in the caudate nuclei. Data are discussed on the positions of theory of the generator, determinant and systemic mechanisms of neuropathological syndromes.