Zied Gaifer1, Ahmed Babiker2, Dawar Rizavi1. 1. Department of Medicine, Sultan Qaboos University Hospital, Al-Khoud, Oman. 2. Department of Internal Medicine, Providence Hospital, Washington D.C, United States of America.
Abstract
OBJECTIVES: The aim of this study was to estimate the prevalence and identify the risk factors for the development of drug-resistant Mycobacterium tuberculosis infection in a tertiary care center in Oman. METHODS: We performed a cross-sectional review of culture-confirmed tuberculosis (TB) cases diagnosed at Sultan Qaboos University Hospital between August 2006 and March 2015. We compared drug-resistant TB cases with drug-sensitive cases to identify predictors of drug-resistant TB using univariate and multivariate logistic regression analysis. RESULTS: Of the 260 TB cases reviewed, 73.1% were confirmed by culture. The proportion of multi-drug resistant TB was 1.8%. TB isolates resistant to any of the first-line TB drugs comprised (7.5%) of cases. Pyrazinamide monoresistance was the most frequently reported drug monoresistant pattern (3.5%). Previous treatment for TB (odds ratio (OR) 14.81; 95% CI 3.09-70.98, p < 0.001), female gender (OR 3.85; 95% Cl 1.07-13.90, p < 0.039), and younger age (OR 6.80; 95% Cl 1.61-28.75, p < 0.009) were found to be risk factors for development of first-line antituberculosis drug-resistant TB in multivariate analysis. CONCLUSIONS: Our results show that the rate of drug-resistant TB in our population is a public health issue of great concern. Previous treatment with antituberculosis drugs, female gender, and younger age are risk factors for the development of drug-resistant TB. These findings are useful adjuvants to guide clinicians and public health professionals in the early detection and appropriate treatment of cases of drug-resistant TB.
OBJECTIVES: The aim of this study was to estimate the prevalence and identify the risk factors for the development of drug-resistant Mycobacterium tuberculosis infection in a tertiary care center in Oman. METHODS: We performed a cross-sectional review of culture-confirmed tuberculosis (TB) cases diagnosed at Sultan Qaboos University Hospital between August 2006 and March 2015. We compared drug-resistant TB cases with drug-sensitive cases to identify predictors of drug-resistant TB using univariate and multivariate logistic regression analysis. RESULTS: Of the 260 TB cases reviewed, 73.1% were confirmed by culture. The proportion of multi-drug resistant TB was 1.8%. TB isolates resistant to any of the first-line TB drugs comprised (7.5%) of cases. Pyrazinamide monoresistance was the most frequently reported drug monoresistant pattern (3.5%). Previous treatment for TB (odds ratio (OR) 14.81; 95% CI 3.09-70.98, p < 0.001), female gender (OR 3.85; 95% Cl 1.07-13.90, p < 0.039), and younger age (OR 6.80; 95% Cl 1.61-28.75, p < 0.009) were found to be risk factors for development of first-line antituberculosis drug-resistant TB in multivariate analysis. CONCLUSIONS: Our results show that the rate of drug-resistant TB in our population is a public health issue of great concern. Previous treatment with antituberculosis drugs, female gender, and younger age are risk factors for the development of drug-resistant TB. These findings are useful adjuvants to guide clinicians and public health professionals in the early detection and appropriate treatment of cases of drug-resistant TB.
Entities:
Keywords:
Oman; Tuberculosis; Tuberculosis, Drug Resistant
Authors: A Al-Maniri; J P Singh; O Al-Rawas; S Al Busaidi; L Al Balushi; I Ahmed; S Al Mahruqi; M Haile; V K Diwan; S Hoffner Journal: Int J Tuberc Lung Dis Date: 2010-08 Impact factor: 2.373
Authors: Keertan Dheda; Tawanda Gumbo; Neel R Gandhi; Megan Murray; Grant Theron; Zarir Udwadia; G B Migliori; Robin Warren Journal: Lancet Respir Med Date: 2014-03-24 Impact factor: 30.700
Authors: M A Espinal; K Laserson; M Camacho; Z Fusheng; S J Kim; R E Tlali; I Smith; P Suarez; M L Antunes; A G George; N Martin-Casabona; P Simelane; K Weyer; N Binkin; M C Raviglione Journal: Int J Tuberc Lung Dis Date: 2001-10 Impact factor: 2.373
Authors: A Mohammadi; Z S Nassor; T Behlim; E Mohammadi; R Govindarajan; A Al Maniri; R A Smego Journal: East Mediterr Health J Date: 2008 Nov-Dec Impact factor: 1.628
Authors: Mohammed S Al-Shahrani; Majed I Hakami; Mahmoud A Younis; Hanan A Fan; Mohammed A Jeraiby; Yasser Alraey Journal: Saudi Med J Date: 2021-07 Impact factor: 1.422