Shizhi He1, Pingdong Li1, Qi Zhong1, Lizhen Hou1, Zhenkun Yu2, Zhigang Huang1, Xuejun Chen1, Jugao Fang1, Xiaohong Chen3. 1. Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China. 2. Department of Otolaryngology-Head and Neck Surgery, Nanjing Tongren Hospital, Jiyin Road 2007, Nanjing, Jiangsu Province 211102, PR China. 3. Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China. Electronic address: trchxh@163.com.
Abstract
PURPOSE: This study was to investigate clinicopathologic characteristics and prognostic factors in adenoid cystic carcinoma of head and neck minor salivary glands. MATERIALS AND METHODS: We conducted a retrospective review of 130 patients with adenoid cystic carcinoma of head and neck minor salivary glands that were evaluated between 2000 and 2013 in Beijng Tongren Hospital. RESULTS: Five-year overall survival and disease-free survival rates were 80.8% and 55.6%. Local recurrence rate was 40%, regional recurrence 3.8%, and distant metastasis was 28.5%. On univariate analysis, solid histological subtype, perineural invasion, positive surgical margins and advanced stages were found to be poor prognostic indicators. On multivariate analysis, solid histological subtype and positive surgical margins were significant prognostic factors of worse overall survival. CONCLUSIONS: Solid histological subtype and positive surgical margins were the most important predictors of poor outcome in adenoid cystic carcinoma of minor salivary glands. Surgery with postoperative radiation were recommended treatment and offered durable local control.
PURPOSE: This study was to investigate clinicopathologic characteristics and prognostic factors in adenoid cystic carcinoma of head and neck minor salivary glands. MATERIALS AND METHODS: We conducted a retrospective review of 130 patients with adenoid cystic carcinoma of head and neck minor salivary glands that were evaluated between 2000 and 2013 in Beijng Tongren Hospital. RESULTS: Five-year overall survival and disease-free survival rates were 80.8% and 55.6%. Local recurrence rate was 40%, regional recurrence 3.8%, and distant metastasis was 28.5%. On univariate analysis, solid histological subtype, perineural invasion, positive surgical margins and advanced stages were found to be poor prognostic indicators. On multivariate analysis, solid histological subtype and positive surgical margins were significant prognostic factors of worse overall survival. CONCLUSIONS: Solid histological subtype and positive surgical margins were the most important predictors of poor outcome in adenoid cystic carcinoma of minor salivary glands. Surgery with postoperative radiation were recommended treatment and offered durable local control.
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