| Literature DB >> 28040699 |
Kami Maddocks1, Paul M Barr1, Bruce D Cheson1, Richard F Little1, Lawrence Baizer1, Brad S Kahl1, John P Leonard1, Nathan Fowler1, Leo I Gordon1, Brian K Link1, Jonathan W Friedberg1, Stephen M Ansell1.
Abstract
Follicular lymphoma (FL) is the second most common lymphoid malignancy, representing 20% to 25% of all cases of non-Hodgkin's lymphoma (NHL), and the most common of the indolent NHLs. FL is considered incurable in the majority of patients with the current standard therapeutic approaches, although outcomes have improved in the last few decades with our current therapies, with a median overall survival that now exceeds 18 years. While the majority of patients with FL have improved outcomes with our current therapeutic approaches, there are patients with high-risk disease features that have inferior outcomes to these therapies. There is an urgent need to integrate novel therapeutic agents into the treatment regimens for these patients to improve outcomes with continued evaluation of biomarkers indicative of prognosis and effects of these regimens on quality of life. Published by Oxford University Press 2016. This work is written by US Government employees and is in the public domain in the US.Entities:
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Year: 2016 PMID： 28040699 PMCID： PMC6059137 DOI： 10.1093/jnci/djw255
Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506