Rita Fonseca1, Francisca Aguiar2, Mariana Rodrigues3, Iva Brito2. 1. Rheumatology Department of São João Hospital Centre, Oporto, Portugal. Electronic address: anaritapfonseca@gmail.com. 2. Rheumatology Department of São João Hospital Centre, Oporto, Portugal. 3. Pediatric Department of São João Hospital Centre, Oporto, Portugal.
Abstract
OBJECTIVE: To study differences in demographic, clinical and immunologic characteristics, activity and cumulative organ damage according to age of onset in systemic lupus erythematosus (SLE). METHODS: Cross-sectional study was performed including 204 SLE patients. Characteristics were compared between juvenile and adult-onset SLE patients using parametric and nonparametric tests (SPSS 23.0). RESULTS: Juvenile-SLE patients had malar rash more often (78.9% vs 53%; p=0.001), oral ulcers (45.5% vs 17.5%; p=0.001), neurological involvement (13.1% vs 3.6%; p=0.02) nephritis (50% vs 33.9%), p=0.04) and haematological manifestations such as hemolytic anaemia (23.6% vs 5.4%; p=0.002) and leukopenia (46.1% vs 4.2%; p<0.001). Arthritis was more prevalent in adult-onset patients (70.9% vs 90%; p<0.04). Overall, 20% of juvenile patients had chronic damage (Systemic Lupus International Collaborating Clinics/Damage Index [SLICC/DI]≥1), However, the percentage of patients with irreversible damage was higher in the adult SLE patient group (24%, p=0.04). No statistically significant differences were found in other characteristics studied. CONCLUSION: In summary, our study confirms the existence of differences in clinical manifestations, according to age at diagnosis of SLE. Juvenile-SLE patients showed a more aggressive clinical presentation.
OBJECTIVE: To study differences in demographic, clinical and immunologic characteristics, activity and cumulative organ damage according to age of onset in systemic lupus erythematosus (SLE). METHODS: Cross-sectional study was performed including 204 SLEpatients. Characteristics were compared between juvenile and adult-onset SLEpatients using parametric and nonparametric tests (SPSS 23.0). RESULTS: Juvenile-SLEpatients had malar rash more often (78.9% vs 53%; p=0.001), oral ulcers (45.5% vs 17.5%; p=0.001), neurological involvement (13.1% vs 3.6%; p=0.02) nephritis (50% vs 33.9%), p=0.04) and haematological manifestations such as hemolytic anaemia (23.6% vs 5.4%; p=0.002) and leukopenia (46.1% vs 4.2%; p<0.001). Arthritis was more prevalent in adult-onset patients (70.9% vs 90%; p<0.04). Overall, 20% of juvenile patients had chronic damage (Systemic Lupus International Collaborating Clinics/Damage Index [SLICC/DI]≥1), However, the percentage of patients with irreversible damage was higher in the adult SLEpatient group (24%, p=0.04). No statistically significant differences were found in other characteristics studied. CONCLUSION: In summary, our study confirms the existence of differences in clinical manifestations, according to age at diagnosis of SLE. Juvenile-SLEpatients showed a more aggressive clinical presentation.
Authors: Paula García-Ríos; María Pilar Pecci-Lloret; Ricardo Elías Oñate-Sánchez Journal: Int J Environ Res Public Health Date: 2022-09-21 Impact factor: 4.614
Authors: J S Massias; E M D Smith; E Al-Abadi; K Armon; K Bailey; C Ciurtin; J Davidson; J Gardner-Medwin; K Haslam; D P Hawley; A Leahy; V Leone; F McErlane; D Mewar; G Modgil; R Moots; C Pilkington; A V Ramanan; S Rangaraj; P Riley; A Sridhar; N Wilkinson; M W Beresford; C M Hedrich Journal: Lupus Date: 2020-03-31 Impact factor: 2.911