| Literature DB >> 28040304 |
Christelle Pomares1, Bo Zhang2, Shylaja Arulkumar3, Geraldine Gonfrier4, Pierre Marty5, Su Zhao3, Steven Cheng3, Meijie Tang3, Hongjie Dai6, Jose G Montoya7.
Abstract
We report the use of the multiplexed T. gondii IgG, IgM test on plasmonic gold (pGOLD) platform in the setting of T. gondii infection by analyzing 244 sera from Nice, France (seroconversion, chronically infected, non-infected and newborns serum samples). Results were compared with commercial tests for the detection of IgG and IgM and their overall clinical final interpretation of a complete serological profile. The IgG and IgM test results on the platform were in agreement in, respectively, 95% and 93% with the commercial kits. When comparing with the overall clinical interpretation of the serological profile, the agreement reached 99.5% and 97.7% for IgG and IgM, respectively. This innovative pGOLD platform allows detection of both IgG and IgM simultaneously with only ~1 microliter of serum. The multiplexed IgG/IgM test on pGOLD platform is a strong candidate for its use in the massive screening programs for toxoplasmosis during pregnancy.Entities:
Keywords: Adults; Multiplex serology; Newborns; Plasmonic gold pGOLD; Seroconversion; Toxoplasma gondii
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Year: 2016 PMID： 28040304 DOI： 10.1016/j.diagmicrobio.2016.09.001
Source DB: PubMed Journal: Diagn Microbiol Infect Dis ISSN： 0732-8893 Impact factor: 2.803