Tomi T Laitinen1, Saku Ruohonen2, Markus Juonala3, Costan G Magnussen4, Vera Mikkilä5, Hanna Mikola2, Nina Hutri-Kähönen6, Tomi Laitinen7, Päivi Tossavainen8, Eero Jokinen9, Harri Niinikoski10, Antti Jula11, Jorma S A Viikari12, Tapani Rönnemaa12, Olli T Raitakari13, Katja Pahkala14. 1. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland. Electronic address: tomi.laitinen@utu.fi. 2. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. 3. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland. 4. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. 5. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Food and Environmental Sciences, University of Helsinki, Finland. 6. Department of Pediatrics, University of Tampere and Tampere University Hospital, Tampere, Finland. 7. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland. 8. Department of Pediatrics, University of Oulu, Oulu, Finland. 9. Department of Pediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. 10. Department of Pediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland. 11. Department of Chronic Disease Prevention, Institute for Health and Welfare, Turku, Finland. 12. Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland. 13. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland. 14. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland.
Abstract
BACKGROUND: Ideal cardiovascular health (CVH), defined by the American Heart Association, is associated with incident cardiovascular disease in adults. However, association of the ideal CVH in childhood with current and future cardiac structure and function has not been studied. METHODS AND RESULTS: The sample comprised 827 children participating in the longitudinal Special Turku Coronary Risk Factor Intervention Project (STRIP) and The Cardiovascular Risk in Young Finns Study (YFS). In STRIP, complete data on the seven ideal CVH metrics and left ventricular (LV) mass measured with echocardiography were available at the age of 15 (n=321), 17 (n=309) and 19 (n=283) years. In YFS, the cohort comprised children aged 12-18years (n=506) with complete ideal CVH metrics data from childhood and 25years later in adulthood, and echocardiography performed in adulthood. In STRIP, ideal CVH score was inversely associated with LV mass during childhood (P=0.036). In YFS, childhood ideal CVH score was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume in adulthood (all P<0.01). In addition, improvement of the ideal CVH score between childhood and adulthood was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume (all P≤0.03). CONCLUSIONS: Childhood ideal CVH score has a long-lasting effect on cardiac structure and function, and the association is evident already in childhood. Our findings support targeting the ideal CVH metrics as part of primordial prevention of cardiovascular diseases.
RCT Entities:
BACKGROUND: Ideal cardiovascular health (CVH), defined by the American Heart Association, is associated with incident cardiovascular disease in adults. However, association of the ideal CVH in childhood with current and future cardiac structure and function has not been studied. METHODS AND RESULTS: The sample comprised 827 children participating in the longitudinal Special Turku Coronary Risk Factor Intervention Project (STRIP) and The Cardiovascular Risk in Young Finns Study (YFS). In STRIP, complete data on the seven ideal CVH metrics and left ventricular (LV) mass measured with echocardiography were available at the age of 15 (n=321), 17 (n=309) and 19 (n=283) years. In YFS, the cohort comprised children aged 12-18years (n=506) with complete ideal CVH metrics data from childhood and 25years later in adulthood, and echocardiography performed in adulthood. In STRIP, ideal CVH score was inversely associated with LV mass during childhood (P=0.036). In YFS, childhood ideal CVH score was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume in adulthood (all P<0.01). In addition, improvement of the ideal CVH score between childhood and adulthood was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume (all P≤0.03). CONCLUSIONS: Childhood ideal CVH score has a long-lasting effect on cardiac structure and function, and the association is evident already in childhood. Our findings support targeting the ideal CVH metrics as part of primordial prevention of cardiovascular diseases.
Authors: Rae-Ellen W Kavey; Cedric Manlhiot; Kyle Runeckles; Tanveer Collins; Samuel S Gidding; Matthew Demczko; Sarah Clauss; Ashraf S Harahsheh; Michele Mietus-Syder; Michael Khoury; Nicolas Madsen; Brian W McCrindle Journal: CJC Open Date: 2020-06-06
Authors: Amber L Fyfe-Johnson; Justin R Ryder; Alvaro Alonso; Richard F MacLehose; Kyle D Rudser; Claudia K Fox; Amy C Gross; Aaron S Kelly Journal: J Am Heart Assoc Date: 2018-04-13 Impact factor: 5.501
Authors: Samuel S Gidding; Donald Lloyd-Jones; Joao Lima; Bharat Ambale-Venkatesh; Sanjiv J Shah; Ravi Shah; Cora E Lewis; David R Jacobs; Norrina B Allen Journal: Circ Heart Fail Date: 2019-09-11 Impact factor: 8.790
Authors: Matthew D Campbell; Tomi T Laitinen; Alun Hughes; Katja Pahkala; Markus Juonala; Mika Kähönen; Tien Y Wong; Terho Lehtimäki; Nina Hutri-Kähönen; Olli T Raitakari; Robyn J Tapp Journal: J Am Heart Assoc Date: 2018-10-16 Impact factor: 5.501