Literature DB >> 28039861

UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects.

Katherine Fahy1, Langni Liu1, Christine M Rapp1, Christina Borchers1, Ji C Bihl1, Yanfang Chen1, Richard Simman1,2, Jeffrey B Travers1,2,3.   

Abstract

Ultraviolet B radiation (UVB) exerts profound effects on human skin. Much is known regarding the ability of UVB to generate a plethora of bioactive agents ranging from cytokines and other bioactive proteins, lipid mediators and microRNAs. It is presumed that these agents are in large part responsible for the effects of UVB, which is only absorbed appreciably in the epidermis. However, the exact mechanism by which these bioactive agents can leave the epidermis are as yet unclear. This review addresses the potential role of microvesicle particles (MVP) as UVB signaling agents through transmitting biologic mediators. New data are provided that UVB treatment of human skin explants also generates MVP production. We hypothesize that UVB production of MVPs (UVB-MVP) could serve this important function of transmitting keratinocyte-derived bioactive agents. Moreover, we propose that UVB-MVP formation involves the lipid mediator platelet-activating factor. This novel pathway has the potential to be exploited pharmacologically to modulate UVB effects.
© 2016 The American Society of Photobiology.

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Year:  2017        PMID： 28039861      PMCID： PMC5494001          DOI： 10.1111/php.12703

Source DB:  PubMed          Journal:  Photochem Photobiol        ISSN： 0031-8655            Impact factor:   3.421


  35 in total

Review 1.  Microparticles as mediators and biomarkers of rheumatic disease.

Authors:  David S Pisetsky; Anirudh J Ullal; Julie Gauley; Tony C Ning
Journal:  Rheumatology (Oxford)       Date:  2012-03-07       Impact factor: 7.580

2.  An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation.

Authors:  Rommel Chacón-Salinas; Limo Chen; Alma D Chávez-Blanco; Alberto Y Limón-Flores; Ying Ma; Stephen E Ullrich
Journal:  J Leukoc Biol       Date:  2013-09-05       Impact factor: 4.962

Review 3.  Preclinical and clinical pharmacology of platelet-activating factor receptor antagonists.

Authors:  D A Handley
Journal:  Med Res Rev       Date:  1990 Jul-Sep       Impact factor: 12.944

Review 4.  Microvesicles as cell-cell messengers in cardiovascular diseases.

Authors:  Xavier Loyer; Anne-Clémence Vion; Alain Tedgui; Chantal M Boulanger
Journal:  Circ Res       Date:  2014-01-17       Impact factor: 17.367

5.  UVA and UVB irradiation differentially regulate microRNA expression in human primary keratinocytes.

Authors:  Anne Kraemer; I-Peng Chen; Stefan Henning; Alexandra Faust; Beate Volkmer; Michael J Atkinson; Simone Moertl; Ruediger Greinert
Journal:  PLoS One       Date:  2013-12-31       Impact factor: 3.240

6.  Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis.

Authors:  Y Pei; L A Barber; R C Murphy; C A Johnson; S W Kelley; L C Dy; R H Fertel; T M Nguyen; D A Williams; J B Travers
Journal:  J Immunol       Date:  1998-08-15       Impact factor: 5.422

7.  ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles.

Authors:  Vandhana Muralidharan-Chari; James Clancy; Carolyn Plou; Maryse Romao; Philippe Chavrier; Graca Raposo; Crislyn D'Souza-Schorey
Journal:  Curr Biol       Date:  2009-11-05       Impact factor: 10.834

8.  Innate immune sensors stimulate inflammatory and immunosuppressive responses to UVB radiation.

Authors:  Richard L Gallo; Jamie J Bernard
Journal:  J Invest Dermatol       Date:  2014-06       Impact factor: 8.551

Review 9.  UV radiation and the skin.

Authors:  John D'Orazio; Stuart Jarrett; Alexandra Amaro-Ortiz; Timothy Scott
Journal:  Int J Mol Sci       Date:  2013-06-07       Impact factor: 5.923

10.  Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release.

Authors:  A Solini; P Chiozzi; A Morelli; R Fellin; F Di Virgilio
Journal:  J Cell Sci       Date:  1999-02       Impact factor: 5.285
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  9 in total

1.  Enhanced Platelet-Activating Factor Synthesis Facilitates Acute and Delayed Effects of Ethanol-Intoxicated Thermal Burn Injury.

Authors:  Kathleen A Harrison; Eric Romer; Jonathan Weyerbacher; Jesus A Ocana; Ravi P Sahu; Robert C Murphy; Lisa E Kelly; Townsend A Smith; Christine M Rapp; Christina Borchers; David R Cool; Gengxin Li; Richard Simman; Jeffrey B Travers
Journal:  J Invest Dermatol       Date:  2018-05-30       Impact factor: 8.551

2.  Acute ethanol exposure stimulates microvesicle particle generation in keratinocytes.

Authors:  Azeezat A Awoyemi; Christina Borchers; Langni Liu; Yanfang Chen; Christine M Rapp; Chad A Brewer; Ramzi Elased; Jeffrey B Travers
Journal:  Toxicol Lett       Date:  2021-11-18       Impact factor: 4.372

Review 3.  UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment.

Authors:  Timothy C Frommeyer; Michael M Gilbert; Garrett V Brittain; Tongfan Wu; Trang Q Nguyen; Craig A Rohan; Jeffrey B Travers
Journal:  Front Immunol       Date:  2022-05-06       Impact factor: 8.786

4.  Evidence for microvesicle particles in UVB-mediated IL-8 generation in keratinocytes.

Authors:  Shweta Bhadri; Pariksha Thapa; Yanfang Chen; Christine M Rapp; Jeffrey B Travers
Journal:  J Clin Investig Dermatol       Date:  2021-12-30

5.  Thermal Burn Injury Generates Bioactive Microvesicles: Evidence for a Novel Transport Mechanism for the Lipid Mediator Platelet-Activating Factor (PAF) That Involves Subcellular Particles and the PAF Receptor.

Authors:  Langni Liu; Katherine E Fahy; Azeezat A Awoyemi; Pariksha Thapa; Lisa E Kelly; Jay Chen; Ji C Bihl; David R Cool; Yanfang Chen; Christine M Rapp; R Michael Johnson; Jeffrey B Travers
Journal:  J Immunol       Date:  2020-05-20       Impact factor: 5.426

6.  Evidence for Systemic Reactive Oxygen Species in UVB-mediated Microvesicle Formation.

Authors:  Cameron L McGlone; Lea Christian; Benjamin Schmeusser; Langni Liu; Charles E Chalfant; Daniel J Stephensen; Catherine M Sherwin; Christine M Rapp; Zafer Sattouf; Craig A Rohan; Connor Morris; Yanfang Chen; Jeffrey B Travers
Journal:  Photochem Photobiol       Date:  2021-08-07       Impact factor: 3.421

7.  Low UVB Fluences Augment Microvesicle Particle Generation in Keratinocytes.

Authors:  Pariksha Thapa; Shweta Bhadri; Christina Borchers; Langni Liu; Yanfang Chen; Christine M Rapp; Jeffrey B Travers
Journal:  Photochem Photobiol       Date:  2021-08-07       Impact factor: 3.521

8.  Platelet-Activating Factor-Receptor Signaling Mediates Targeted Therapies-Induced Microvesicle Particles Release in Lung Cancer Cells.

Authors:  Shreepa J Chauhan; Anita Thyagarajan; Yanfang Chen; Jeffrey B Travers; Ravi P Sahu
Journal:  Int J Mol Sci       Date:  2020-11-12       Impact factor: 5.923

Review 9.  New Insights Into the Pathologic Roles of the Platelet-Activating Factor System.

Authors:  Jeffrey B Travers; Joyce G Rohan; Ravi P Sahu
Journal:  Front Endocrinol (Lausanne)       Date:  2021-03-15       Impact factor: 6.055
  9 in total

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