Orkun Cetin1, Erbil Karaman2, Harun Arslan3, Ibrahim Akbudak3, Recep Yildizhan2, Ali Kolusari2. 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Yuzuncu Yil University, Dursun Odabas Tip Merkezi, Kampus, 65080, Van, Turkey. drorkuncetin34@hotmail.com. 2. Department of Obstetrics and Gynecology, Faculty of Medicine, Yuzuncu Yil University, Dursun Odabas Tip Merkezi, Kampus, 65080, Van, Turkey. 3. Department of Radiology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
Abstract
PURPOSE: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus and impaired liver function. The objective of the study was to evaluate maternal liver elasticity by acoustic radiation force impulse (ARFI) elastosonography in ICP and to compare it with that in healthy pregnant women. METHODS: This descriptive, case-control study consisted of 33 women with healthy pregnancies and 22 women with ICP in the third trimester of gestation. Maternal liver elasticity measurements were performed by ARFI elastosonography. The maternal characteristics and perinatal outcomes of the participants were also collected. RESULTS: All maternal liver ARFI elastosonography scores were elevated in women with ICP compared to healthy controls (p = 0.015, p = 0.011, and p = 0.004, respectively). There was a significant positive correlation between maternal liver enzymes and ARFI elastosonography scores (r = 0.404, p = 0.002 and r = 0.389, p = 0.003, respectively). The optimal cut-off point of maternal liver ARFI-mean elastography score to identify the risk of ICP was >1.23 m/s, and the sensitivity and specificity were 68.2 and 69.7%, respectively [area under curve (AUC) 0.731, 95% confidence interval (CI) 0.594-0.869). CONCLUSION: The current study found that maternal liver stiffness measured by ARFI elastosonography was increased in pregnancies complicated with ICP.
PURPOSE:Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus and impaired liver function. The objective of the study was to evaluate maternal liver elasticity by acoustic radiation force impulse (ARFI) elastosonography in ICP and to compare it with that in healthy pregnant women. METHODS: This descriptive, case-control study consisted of 33 women with healthy pregnancies and 22 women with ICP in the third trimester of gestation. Maternal liver elasticity measurements were performed by ARFI elastosonography. The maternal characteristics and perinatal outcomes of the participants were also collected. RESULTS: All maternal liver ARFI elastosonography scores were elevated in women with ICP compared to healthy controls (p = 0.015, p = 0.011, and p = 0.004, respectively). There was a significant positive correlation between maternal liver enzymes and ARFI elastosonography scores (r = 0.404, p = 0.002 and r = 0.389, p = 0.003, respectively). The optimal cut-off point of maternal liver ARFI-mean elastography score to identify the risk of ICP was >1.23 m/s, and the sensitivity and specificity were 68.2 and 69.7%, respectively [area under curve (AUC) 0.731, 95% confidence interval (CI) 0.594-0.869). CONCLUSION: The current study found that maternal liver stiffness measured by ARFI elastosonography was increased in pregnancies complicated with ICP.
Entities:
Keywords:
Acoustic radiation force impulse; Elasticity; Elastosonography; Intrahepatic cholestasis of pregnancy; Maternal liver
Authors: Simona Bota; Harald Herkner; Ioan Sporea; Petra Salzl; Roxana Sirli; Adriana M Neghina; Markus Peck-Radosavljevic Journal: Liver Int Date: 2013-07-16 Impact factor: 5.828