Ivan Müller1,2,3, Lindsey Beyleveld4, Markus Gerber3, Uwe Pühse3, Rosa du Randt5, Jürg Utzinger1,2, Leyli Zondie4, Cheryl Walter5, Peter Steinmann6,2. 1. Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland. 2. University of Basel, P.O. Box, CH-4003 Basel, Switzerland. 3. Department of Sport, Exercise and Health, University of Basel, St. Jakobsturm, Birsstrasse 320B, CH-4056 Basel, Switzerland. 4. Department of Medical Laboratory Sciences, Nelson Mandela Metropolitan University, P.O. Box 77000, Port Elizabeth 6031, South Africa. 5. Department of Human Movement Science, Nelson Mandela Metropolitan University, P.O. Box 77000, Port Elizabeth 6031, South Africa. 6. Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland peter.steinmann@unibas.ch.
Abstract
BACKGROUND: Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis. METHODS: A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears before and 2 weeks after administration of albendazole (400 mg). RESULTS: Trichuris trichiura was the predominant soil-transmitted helminth species (prevalence 60.4%), followed by Ascaris lumbricoides (47.7%). While albendazole was highly efficacious against A. lumbricoides (cure rate [CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%). CONCLUSIONS: Our study confirms low efficacy of single dose albendazole against T. trichiura. There is a need for safe and efficacious drugs against T. trichiura.
BACKGROUND:Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis. METHODS: A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears before and 2 weeks after administration of albendazole (400 mg). RESULTS:Trichuris trichiura was the predominant soil-transmitted helminth species (prevalence 60.4%), followed by Ascaris lumbricoides (47.7%). While albendazole was highly efficacious against A. lumbricoides (cure rate [CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%). CONCLUSIONS: Our study confirms low efficacy of single dose albendazole against T. trichiura. There is a need for safe and efficacious drugs against T. trichiura.
Authors: Ivan Müller; Christian Schindler; Larissa Adams; Katharina Endes; Stefanie Gall; Markus Gerber; Nan S N Htun; Siphesihle Nqweniso; Nandi Joubert; Nicole Probst-Hensch; Rosa du Randt; Harald Seelig; Danielle Smith; Peter Steinmann; Jürg Utzinger; Peiling Yap; Cheryl Walter; Uwe Pühse Journal: Int J Environ Res Public Health Date: 2019-01-15 Impact factor: 3.390
Authors: Mian Zi Tee; Soo Ching Lee; Yi Xian Er; Nan Jiun Yap; Romano Ngui; Alice V Easton; Vinnie Wei Yin Siow; Kee Seong Ng; Christopher Chiong Meng Boey; Kek Heng Chua; Ken Cadwell; P'ng Loke; Yvonne Ai Lian Lim Journal: PLoS One Date: 2022-08-12 Impact factor: 3.752