Josephine Brice1,2, Mariam Sylla3, Sophie Sayon1,2, Fatoumata Telly4, Djeneba Bocar-Fofana1,2, Robert Murphy5, Sidonie Lambert-Niclot1,2, Eve Todesco1,2, Maxime Grude1,2, Francis Barin6, Souleymane Diallo4, Deenan Pillay7, Anne Derache7, Vincent Calvez1,2, Anne-Geneviève Marcelin1,2, Almoustapha Issiaka Maiga4,8. 1. Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris F75013, France. 2. Department of Virology, Hôpital Pitié-Salpêtrière, AP-HP, Paris F75013, France. 3. Department of Pediatric, University Hospital Gabriel Toure, Bamako, Mali. 4. Unité d'Epidémiologie Moléculaire de la Résistance du VIH aux ARV, SEREFO, FMOS, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali. 5. Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, 645 N Michigan Avenue, Suite 900, Chicago, IL 60611, USA. 6. CHRU de Tours, French reference centre of HIV, Virologic laboratory, Tours, France. 7. Africa Health Research Institute, Durban, South Africa. 8. Clinical and Microbiology Laboratory, University Hospital Gabriel Toure, Bamako, Mali.
Abstract
Background: Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation of HAART could lead to functional cure. Objectives: We described the factors associated with HIV antibody levels and the viral reservoir size in HAART-treated VHIV children. Methods: Study included 97 VHIV children with virological suppression, in Bamako, Mali. The anti-gp41 antibody activities and HIV serostatus were assessed. The viral reservoir size was measured by quantifying total cell-associated HIV DNA. Results: Among the children studied, the median total HIV DNA level was 445 copies/10 6 cells (IQR = 187-914) and the median anti-gp41 antibody activity was 0.29 OD (IQR = 0.18-0.75). Low activity of anti-gp41 antibodies was associated with a younger age of HAART initiation ( P = 0.01). Overall, eight HIV-1 seroreversions were identified. Conclusions: Study identified potential candidates with low viral reservoir and low antibody levels or activities for future trials aiming to reduce HIV-1 reservoir to limit HAART duration.
Background: Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation of HAART could lead to functional cure. Objectives: We described the factors associated with HIV antibody levels and the viral reservoir size in HAART-treated VHIV children. Methods: Study included 97 VHIV children with virological suppression, in Bamako, Mali. The anti-gp41 antibody activities and HIV serostatus were assessed. The viral reservoir size was measured by quantifying total cell-associated HIV DNA. Results: Among the children studied, the median total HIV DNA level was 445 copies/10 6 cells (IQR = 187-914) and the median anti-gp41 antibody activity was 0.29 OD (IQR = 0.18-0.75). Low activity of anti-gp41 antibodies was associated with a younger age of HAART initiation ( P = 0.01). Overall, eight HIV-1 seroreversions were identified. Conclusions: Study identified potential candidates with low viral reservoir and low antibody levels or activities for future trials aiming to reduce HIV-1 reservoir to limit HAART duration.
Authors: Nancie M Archin; Naveen K Vaidya; Joann D Kuruc; Abigail L Liberty; Ann Wiegand; Mary F Kearney; Myron S Cohen; John M Coffin; Ronald J Bosch; Cynthia L Gay; Joseph J Eron; David M Margolis; Alan S Perelson Journal: Proc Natl Acad Sci U S A Date: 2012-05-29 Impact factor: 11.205
Authors: Ari Bitnun; Doris G Ransy; Jason Brophy; Fatima Kakkar; Michael Hawkes; Lindy Samson; Bayader Annabi; Amélie Pagliuzza; Jacob-Adams Morand; Laura Sauve; Nicolas Chomont; Stephanie Lavoie; John Kim; Paul Sandstrom; Paul A Wender; Terry Lee; Joel Singer; Stanley E Read; Hugo Soudeyns Journal: Clin Infect Dis Date: 2020-02-14 Impact factor: 9.079
Authors: Margaret McManus; Jennifer Henderson; Anita Gautam; Robin Brody; Eric R Weiss; Deborah Persaud; Eric Mick; Katherine Luzuriaga Journal: Clin Infect Dis Date: 2019-05-02 Impact factor: 9.079
Authors: Kirsten A Veldsman; Barbara Laughton; Anita Janse van Rensburg; Peter Zuidewind; Els Dobbels; Shaun Barnabas; Samantha Fry; Mark F Cotton; Gert U van Zyl Journal: AIDS Date: 2021-07-01 Impact factor: 4.632