| Literature DB >> 28035825 |
Alicia Castelló-Micó1, Julia Nafe1, Kosuke Higashida1, Konstantin Karaghiosoff1, Marc Gingras2, Paul Knochel1.
Abstract
TMPMgCl·LiCl and TMPZnCl·LiCl allow facile magnesiation and zincation, respectively, of the 1,4-dithiin scaffold, producing polyfunctionalized 1,4-dithiins. A subsequent metalation of these S-heterocycles can also be achieved with the same TMP bases, leading to 2,3-disubstituted-1,4-dithiins. The Mg- and Zn-TMP bases allow as well the successful metalation of 1,4,5,8-tetrathianaphthalene and 1,4,5,6,9,10-hexathiaanthracene.Entities:
Year: 2016 PMID： 28035825 DOI： 10.1021/acs.orglett.6b03539
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005